Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA077570-03
Application #
6342081
Study Section
Hematology Subcommittee 2 (HEM)
Program Officer
Mufson, R Allan
Project Start
1999-01-18
Project End
2003-12-31
Budget Start
2001-01-01
Budget End
2001-12-31
Support Year
3
Fiscal Year
2001
Total Cost
$245,679
Indirect Cost
Name
University of Pennsylvania
Department
Pathology
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Wertheim, Jason A; Perera, Samanthi A; Hammer, Daniel A et al. (2003) Localization of BCR-ABL to F-actin regulates cell adhesion but does not attenuate CML development. Blood 102:2220-8
Wertheim, Jason A; Miller, Juli P; Xu, Lanwei et al. (2002) The biology of chronic myelogenous leukemia:mouse models and cell adhesion. Oncogene 21:8612-28
Wertheim, Jason A; Forsythe, Kevin; Druker, Brian J et al. (2002) BCR-ABL-induced adhesion defects are tyrosine kinase-independent. Blood 99:4122-30
Zhang, X; Wong, R; Hao, S X et al. (2001) The SH2 domain of bcr-Abl is not required to induce a murine myeloproliferative disease; however, SH2 signaling influences disease latency and phenotype. Blood 97:277-87
Quackenbush, R C; Reuther, G W; Miller, J P et al. (2000) Analysis of the biologic properties of p230 Bcr-Abl reveals unique and overlapping properties with the oncogenic p185 and p210 Bcr-Abl tyrosine kinases. Blood 95:2913-21