Magnetic Resonance imaging (MRI) has potential to greatly improve detection and staging of breast cancer. The major problem which must be addressed before MRI can be used in this capacity is its lack of specificity. MRI does not provide enough information regarding lesion composition, shape, and contrast media uptake to reliably differentiate between benign and malignant lesions. This is due in part to strong magnetic susceptibility gradients in tumors and heterogeneous lipid signals which cause blurring, loss of contrast, poor edge delineation, and distortion - and thus reduce the ability of radiologists to characterize lesions. These artifacts can be minimized if high resolution proton spectra are acquired for each image voxel. We believe that this can be accomplished through use of Fast Spectroscopic Imaging (FSI) to calculate what the proton resonance in each voxel would look like in the absence of magnetic susceptibility and chemical shift effects. We have used FSI to obtain excellent separation between water and fat signals and significantly improved delineation of edges and texture with clinically acceptable run times in animal models. The goal of the work proposed here is to implement FSI pulse sequences and data analysis on a whole body scanner, optimize FSI using a phantom, test FSI with and without contrast in patients with suspicious breast lesions, and compare FSI with conventional MRI, mammography, and biopsy results. Successful completion of the proposed work will produce FSI methods which can easily be used in a clinical setting. This would be a significant advance in clinical MRI. Specifically - FSI with high spectral and spatial resolution would increase image contrast and signal-to-noise ratio, and improve edge delineation, image resolution and the accuracy of positional information.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA078803-02
Application #
6174317
Study Section
Diagnostic Radiology Study Section (RNM)
Program Officer
Torres-Anjel, Manuel J
Project Start
1999-09-01
Project End
2002-08-31
Budget Start
2000-09-13
Budget End
2001-08-31
Support Year
2
Fiscal Year
2000
Total Cost
$186,101
Indirect Cost
Name
University of Chicago
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
225410919
City
Chicago
State
IL
Country
United States
Zip Code
60637
Mustafi, Devkumar; Zamora, Marta; Fan, Xiaobing et al. (2015) MRI accurately identifies early murine mammary cancers and reliably differentiates between in situ and invasive cancer: correlation of MRI with histology. NMR Biomed 28:1078-86
Bhooshan, Neha; Giger, Maryellen; Medved, Milica et al. (2014) Potential of computer-aided diagnosis of high spectral and spatial resolution (HiSS) MRI in the classification of breast lesions. J Magn Reson Imaging 39:59-67
Wood, Abbie M; Medved, Milica; Bacchus, Ian D et al. (2013) Classification of breast lesions pre-contrast injection using water resonance lineshape analysis. NMR Biomed 26:569-77
Medved, Milica; Karczmar, Gregory S; Newstead, Gillian M (2012) Do we really need contrast agents? Eur J Radiol 81 Suppl 1:S99-100
Medved, Milica; Fan, Xiaobing; Abe, Hiroyuki et al. (2011) Non-contrast enhanced MRI for evaluation of breast lesions: comparison of non-contrast enhanced high spectral and spatial resolution (HiSS) images versus contrast enhanced fat-suppressed images. Acad Radiol 18:1467-74
Medved, Milica; Newstead, Gillian M; Abe, Hiroyuki et al. (2010) Clinical implementation of a multislice high spectral and spatial resolution-based MRI sequence to achieve unilateral full-breast coverage. Magn Reson Imaging 28:16-21
Medved, Milica; Ivancevic, Marko K; Olopade, Olufunmilayo I et al. (2010) Echo-planar spectroscopic imaging (EPSI) of the water resonance structure in human breast using sensitivity encoding (SENSE). Magn Reson Med 63:1557-63
Medved, Milica; Newstead, Gillian M; Fan, Xiaobing et al. (2009) Fourier component imaging of water resonance in the human breast provides markers for malignancy. Phys Med Biol 54:5767-79
Fan, Xiaobing; Karczmar, Gregory S (2009) A new approach to analysis of the impulse response function (IRF) in dynamic contrast-enhanced MRI (DCEMRI): a simulation study. Magn Reson Med 62:229-39
Jansen, Sanaz A; Fan, Xiaobing; Karczmar, Gregory S et al. (2008) DCEMRI of breast lesions: is kinetic analysis equally effective for both mass and nonmass-like enhancement? Med Phys 35:3102-9

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