The Jerusalem Perinatal Study is a population-based research data bank based on mothers, fathers and offspring. In 1964-76 all Jewish births were surveyed, as were all births to Arab residents of West Jerusalem. Demographic data were recorded on the parents, infant deaths and congenital malformations, admissions to hospitals and obstetric complications. Approximately two thirds of the Jews were refugees, or their offspring, from Morocco, Algeria, Tunisia, Egypt, Iraq, Iran, Turkey, Yemen, Syria or Lebanon. Specific subsets of the mothers were interviewed in 1966-68 and 1975-76, adding information on consanguinity, antenatal health, body size, smoking, fertility, gynecologic variables and contraceptive use. After an average of 27 years (range 21-33) most offspring have completed their compulsory military service. This cohort may be one of the largest to include ethnic ancestry with obstetric and social data, which can link siblings and parents. We propose to link this database with Israel's Cancer Registry for follow-up studies of malignancies, as the parents and offspring age, and to prepare for the potential use of this cohort for cancer prevention trials. In this initial 4-year project we will undertake the checking and corrections needed for record linkage, describe losses to follow up, identify deaths and update the record linkage annually. Linkage in 1999 will identify malignancies diagnosed to the end of 1996, including an estimated 1846 cases in the 34,900 mothers and 485 in the 92,500 male and female offspring. We estimate there will be 440 cancers of breast and 122 of ovary, half of them to women of non-European origin. Focussing on breast cancer in mothers we will test for effects of gender of first offspring and explore ethnic differences in the effects of these and conventional risk factors. We will question whether changes in incidence of breast cancer and or other cancers can be predicted by births of offspring with major or minor birth defects, including neural tube defects and Down's syndrome, or by certain obstetric outcomes, including pre-eclampsia. The results may identify women who would benefit from intensive screening or provide new clues to the etiology of breast cancer.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA080197-03
Application #
6377008
Study Section
Special Emphasis Panel (ZRG4-EDC-2 (02))
Project Start
1999-06-15
Project End
2003-03-31
Budget Start
2001-04-01
Budget End
2002-03-31
Support Year
3
Fiscal Year
2001
Total Cost
$480,955
Indirect Cost
Name
New York University
Department
Obstetrics & Gynecology
Type
Schools of Medicine
DUNS #
City
New York
State
NY
Country
United States
Zip Code
10016
Groeger, J; Opler, M; Kleinhaus, K et al. (2017) Live birth sex ratios and father's geographic origins in Jerusalem, 1964-1976. Am J Hum Biol 29:
Dior, Uri P; Lawrence, Gabriella M; Sitlani, Colleen et al. (2014) Parental smoking during pregnancy and offspring cardio-metabolic risk factors at ages 17 and 32. Atherosclerosis 235:430-7
Dior, Uri P; Hochner, Hagit; Friedlander, Yechiel et al. (2013) Association between number of children and mortality of mothers: results of a 37-year follow-up study. Ann Epidemiol 23:13-8
Kleinhaus, Karine; Harlap, Susan; Perrin, Mary C et al. (2012) Catatonic schizophrenia: a cohort prospective study. Schizophr Bull 38:331-7
Hochner, Hagit; Friedlander, Yechiel; Calderon-Margalit, Ronit et al. (2012) Associations of maternal prepregnancy body mass index and gestational weight gain with adult offspring cardiometabolic risk factors: the Jerusalem Perinatal Family Follow-up Study. Circulation 125:1381-9
Chen, Jinbo; Lin, Dongyu; Hochner, Hagit (2012) Semiparametric maximum likelihood methods for analyzing genetic and environmental effects with case-control mother-child pair data. Biometrics 68:869-77
Kleinhaus, K; Harlap, S; Perrin, M et al. (2011) Age, sex and first treatment of schizophrenia in a population cohort. J Psychiatr Res 45:136-41
Opler, Mark G A; Harlap, Susan; Ornstein, Katherine et al. (2010) Time-to-pregnancy and risk of schizophrenia. Schizophr Res 118:76-80
Corcoran, Cheryl; Perrin, Mary; Harlap, Susan et al. (2009) Effect of socioeconomic status and parents' education at birth on risk of schizophrenia in offspring. Soc Psychiatry Psychiatr Epidemiol 44:265-71
Harlap, S; Perrin, M C; Deutsch, L et al. (2009) Schizophrenia and birthplace of paternal and maternal grandfather in the Jerusalem perinatal cohort prospective study. Schizophr Res 111:23-31

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