Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA080361-03
Application #
6329081
Study Section
Experimental Therapeutics Subcommittee 1 (ET)
Program Officer
Lees, Robert G
Project Start
1998-12-10
Project End
2003-11-30
Budget Start
2000-12-01
Budget End
2001-11-30
Support Year
3
Fiscal Year
2001
Total Cost
$211,936
Indirect Cost

  Institution

Name
University of South Carolina at Columbia
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
111310249
City
Columbia
State
SC
Country
United States
Zip Code
29208

  Publications

Pena, Maria Marjorette O; Xing, Yang Yang; Koli, Sangita et al. (2006) Role of N-terminal residues in the ubiquitin-independent degradation of human thymidylate synthase. Biochem J 394:355-63
Murphy, John T; Tucker, Jody M; Davis, Celestia et al. (2004) Raltitrexed increases tumorigenesis as a single agent yet exhibits anti-tumor synergy with 5-fluorouracil in ApcMin/+ mice. Cancer Biol Ther 3:1169-76
Berger, Sondra H; Berger, Franklin G; Lebioda, Lukasz (2004) Effects of ligand binding and conformational switching on intracellular stability of human thymidylate synthase. Biochim Biophys Acta 1696:15-22
Forsthoefel, Antonia M; Pena, Maria Marjorette O; Xing, Yang Yang et al. (2004) Structural determinants for the intracellular degradation of human thymidylate synthase. Biochemistry 43:1972-9