Ornithine Decarboxylase and Ras Transformation

Shantz, Lisa M.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Cancer Institute (NCI)
• Type: Research Project (R01)
• Project #: 5R01CA082768-03
• Application #: 6377421
• Study Section: Metabolic Pathology Study Section (MEP)
• Program Officer: Moshell, Alan N
• Project Start: 1999-07-01
• Project End: 2002-06-30
• Budget Start: 2001-07-01
• Budget End: 2002-06-30
• Support Year: 3
• Fiscal Year: 2001
• Total Cost: $180,229

Institution

• Name: Pennsylvania State University
• Department: Physiology
• Type: Schools of Medicine
• DUNS #: 129348186
• City: Hershey
• State: PA
• Country: United States
• Zip Code: 17033

Publications

Nowotarski, Shannon L; Feith, David J; Shantz, Lisa M (2015) Skin Carcinogenesis Studies Using Mouse Models with Altered Polyamines. Cancer Growth Metastasis 8:17-27

Shi, Chenxu; Cooper, Timothy K; McCloskey, Diane E et al. (2012) S-adenosylmethionine decarboxylase overexpression inhibits mouse skin tumor promotion. Carcinogenesis 33:1310-8

Origanti, Sofia; Nowotarski, Shannon L; Carr, Theresa D et al. (2012) Ornithine decarboxylase mRNA is stabilized in an mTORC1-dependent manner in Ras-transformed cells. Biochem J 442:199-207

Nowotarski, Shannon L; Origanti, Sofia; Shantz, Lisa M (2011) Posttranscriptional regulation of ornithine decarboxylase. Methods Mol Biol 720:279-92

Nowotarski, Shannon L; Shantz, Lisa M (2010) Cytoplasmic accumulation of the RNA-binding protein HuR stabilizes the ornithine decarboxylase transcript in a murine nonmelanoma skin cancer model. J Biol Chem 285:31885-94

Levin, Victor A; Jochec, Jacob L; Shantz, Lisa M et al. (2007) Relationship between ornithine decarboxylase levels in anaplastic gliomas and progression-free survival in patients treated with DFMO-PCV chemotherapy. Int J Cancer 121:2279-83

Feith, David J; Shantz, Lisa M; Shoop, Paula L et al. (2007) Mouse skin chemical carcinogenesis is inhibited by antizyme in promotion-sensitive and promotion-resistant genetic backgrounds. Mol Carcinog 46:453-65

Origanti, Sofia; Shantz, Lisa M (2007) Ras transformation of RIE-1 cells activates cap-independent translation of ornithine decarboxylase: regulation by the Raf/MEK/ERK and phosphatidylinositol 3-kinase pathways. Cancer Res 67:4834-42

Feith, David J; Origanti, Sofia; Shoop, Paula L et al. (2006) Tumor suppressor activity of ODC antizyme in MEK-driven skin tumorigenesis. Carcinogenesis 27:1090-8

Kim, Sonia W; Mangold, Ursula; Waghorne, Carol et al. (2006) Regulation of cell proliferation by the antizyme inhibitor: evidence for an antizyme-independent mechanism. J Cell Sci 119:2583-91