Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA085410-03
Application #
6514401
Study Section
Special Emphasis Panel (ZRG1-SSS-1 (03))
Program Officer
Freeman, Colette S
Project Start
2000-03-01
Project End
2005-02-28
Budget Start
2002-03-01
Budget End
2003-02-28
Support Year
3
Fiscal Year
2002
Total Cost
$282,956
Indirect Cost

  Institution

Name
University of North Carolina Chapel Hill
Department
Biochemistry
Type
Schools of Medicine
DUNS #
078861598
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599

  Publications

Myers, Timothy J; Brennaman, Leann H; Stevenson, Mary et al. (2009) Mitochondrial reactive oxygen species mediate GPCR-induced TACE/ADAM17-dependent transforming growth factor-alpha shedding. Mol Biol Cell 20:5236-49
Sternlicht, Mark D; Sunnarborg, Susan W (2008) The ADAM17-amphiregulin-EGFR axis in mammary development and cancer. J Mammary Gland Biol Neoplasia 13:181-94
Federici, Massimo; Hribal, Marta L; Menghini, Rossella et al. (2005) Timp3 deficiency in insulin receptor-haploinsufficient mice promotes diabetes and vascular inflammation via increased TNF-alpha. J Clin Invest 115:3494-505
Sternlicht, Mark D; Sunnarborg, Susan W; Kouros-Mehr, Hosein et al. (2005) Mammary ductal morphogenesis requires paracrine activation of stromal EGFR via ADAM17-dependent shedding of epithelial amphiregulin. Development 132:3923-33
Lautrette, Alexandre; Li, Shunqiang; Alili, Rohia et al. (2005) Angiotensin II and EGF receptor cross-talk in chronic kidney diseases: a new therapeutic approach. Nat Med 11:867-74
Hinkle, C Leann; Sunnarborg, Susan W; Loiselle, David et al. (2004) Selective roles for tumor necrosis factor alpha-converting enzyme/ADAM17 in the shedding of the epidermal growth factor receptor ligand family: the juxtamembrane stalk determines cleavage efficiency. J Biol Chem 279:24179-88
Lee, David C; Sunnarborg, Susan Wohler; Hinkle, C Leann et al. (2003) TACE/ADAM17 processing of EGFR ligands indicates a role as a physiological convertase. Ann N Y Acad Sci 995:22-38
Jackson, Leslie F; Qiu, Ting Hu; Sunnarborg, Susan W et al. (2003) Defective valvulogenesis in HB-EGF and TACE-null mice is associated with aberrant BMP signaling. EMBO J 22:2704-16
Raska, Christina S; Parker, Carol E; Sunnarborg, Susan W et al. (2003) Rapid and sensitive identification of epitope-containing peptides by direct matrix-assisted laser desorption/ionization tandem mass spectrometry of peptides affinity-bound to antibody beads. J Am Soc Mass Spectrom 14:1076-85
Sunnarborg, Susan Wohler; Hinkle, C Leann; Stevenson, Mary et al. (2002) Tumor necrosis factor-alpha converting enzyme (TACE) regulates epidermal growth factor receptor ligand availability. J Biol Chem 277:12838-45