Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA085605-03
Application #
6514430
Study Section
Radiation Study Section (RAD)
Program Officer
Pelroy, Richard
Project Start
2000-04-01
Project End
2004-03-31
Budget Start
2002-04-01
Budget End
2003-03-31
Support Year
3
Fiscal Year
2002
Total Cost
$195,075
Indirect Cost
Name
University of Texas Health Science Center San Antonio
Department
Other Basic Sciences
Type
Schools of Medicine
DUNS #
800772162
City
San Antonio
State
TX
Country
United States
Zip Code
78229
Chen, Phang-Lang; Liu, Feng; Cai, Suna et al. (2005) Inactivation of CtIP leads to early embryonic lethality mediated by G1 restraint and to tumorigenesis by haploid insufficiency. Mol Cell Biol 25:3535-42
Peng, Aimin; Chen, Phang-Lang (2005) NFBD1/Mdc1 mediates ATR-dependent DNA damage response. Cancer Res 65:1158-63
Polci, Rosaria; Peng, Aimin; Chen, Phang-Lang et al. (2004) NIMA-related protein kinase 1 is involved early in the ionizing radiation-induced DNA damage response. Cancer Res 64:8800-3
Wu, Guikai; Jiang, Xianzhi; Lee, Wen-Hwa et al. (2003) Assembly of functional ALT-associated promyelocytic leukemia bodies requires Nijmegen Breakage Syndrome 1. Cancer Res 63:2589-95
Shang, Yong Lei; Bodero, Amanda J; Chen, Phang-Lang (2003) NFBD1, a novel nuclear protein with signature motifs of FHA and BRCT, and an internal 41-amino acid repeat sequence, is an early participant in DNA damage response. J Biol Chem 278:6323-9
Peng, Aimin; Chen, Phang-Lang (2003) NFBD1, like 53BP1, is an early and redundant transducer mediating Chk2 phosphorylation in response to DNA damage. J Biol Chem 278:8873-6
Zhong, Qing; Boyer, Thomas G; Chen, Phang-Lang et al. (2002) Deficient nonhomologous end-joining activity in cell-free extracts from Brca1-null fibroblasts. Cancer Res 62:3966-70
Zhong, Qing; Chen, Chi-Fen; Chen, Phang-Lang et al. (2002) BRCA1 facilitates microhomology-mediated end joining of DNA double strand breaks. J Biol Chem 277:28641-7
Wu, G; Lee, W H; Chen, P L (2000) NBS1 and TRF1 colocalize at promyelocytic leukemia bodies during late S/G2 phases in immortalized telomerase-negative cells. Implication of NBS1 in alternative lengthening of telomeres. J Biol Chem 275:30618-22