Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA085704-04
Application #
6633672
Study Section
Radiation Study Section (RAD)
Program Officer
Stone, Helen B
Project Start
2000-03-01
Project End
2005-02-28
Budget Start
2003-03-01
Budget End
2004-02-29
Support Year
4
Fiscal Year
2003
Total Cost
$365,175
Indirect Cost
Name
Sloan-Kettering Institute for Cancer Research
Department
Type
DUNS #
064931884
City
New York
State
NY
Country
United States
Zip Code
10065
Stancevic, Branka; Varda-Bloom, Nira; Cheng, Jin et al. (2013) Adenoviral transduction of human acid sphingomyelinase into neo-angiogenic endothelium radiosensitizes tumor cure. PLoS One 8:e69025
Rotolo, Jimmy; Stancevic, Branka; Zhang, Jianjun et al. (2012) Anti-ceramide antibody prevents the radiation gastrointestinal syndrome in mice. J Clin Invest 122:1786-90
Lee, Hyunmi; Rotolo, Jimmy A; Mesicek, Judith et al. (2011) Mitochondrial ceramide-rich macrodomains functionalize Bax upon irradiation. PLoS One 6:e19783
Truman, Jean-Philip; Garcia-Barros, Monica; Kaag, Matthew et al. (2010) Endothelial membrane remodeling is obligate for anti-angiogenic radiosensitization during tumor radiosurgery. PLoS One 5:
Rotolo, Jimmy A; Mesicek, Judith; Maj, Jerzy et al. (2010) Regulation of ceramide synthase-mediated crypt epithelium apoptosis by DNA damage repair enzymes. Cancer Res 70:957-67
Stancevic, Branka; Kolesnick, Richard (2010) Ceramide-rich platforms in transmembrane signaling. FEBS Lett 584:1728-40
Truman, Jean-Philip; Garcia-Barros, Monica; Kaag, Matthew et al. (2010) Endothelial membrane remodeling is obligate for anti-angiogenic radiosensitization during tumor radiosurgery. PLoS One 5:e12310
Mesicek, Judith; Lee, Hyunmi; Feldman, Taya et al. (2010) Ceramide synthases 2, 5, and 6 confer distinct roles in radiation-induced apoptosis in HeLa cells. Cell Signal 22:1300-7
Garcia-Barros, Monica; Thin, Tin Htwe; Maj, Jerzy et al. (2010) Impact of stromal sensitivity on radiation response of tumors implanted in SCID hosts revisited. Cancer Res 70:8179-86
Truman, Jean-Philip; Rotenberg, Susan A; Kang, Ji-Hye et al. (2009) PKCalpha activation downregulates ATM and radio-sensitizes androgen-sensitive human prostate cancer cells in vitro and in vivo. Cancer Biol Ther 8:54-63

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