Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA085912-05
Application #
6761753
Study Section
Metabolic Pathology Study Section (MEP)
Program Officer
Sussman, Daniel J
Project Start
2000-06-01
Project End
2005-05-31
Budget Start
2004-06-01
Budget End
2005-05-31
Support Year
5
Fiscal Year
2004
Total Cost
$264,884
Indirect Cost
Name
Dana-Farber Cancer Institute
Department
Type
DUNS #
076580745
City
Boston
State
MA
Country
United States
Zip Code
02215
Robinson, Dan; Van Allen, Eliezer M; Wu, Yi-Mi et al. (2015) Integrative clinical genomics of advanced prostate cancer. Cell 161:1215-1228
Rabinovsky, Rosalia; Pochanard, Panisa; McNear, Chontelle et al. (2009) p85 Associates with unphosphorylated PTEN and the PTEN-associated complex. Mol Cell Biol 29:5377-88
Vasudevan, Krishna M; Barbie, David A; Davies, Michael A et al. (2009) AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer. Cancer Cell 16:21-32
Sansal, Isabelle; Sellers, William R (2004) The biology and clinical relevance of the PTEN tumor suppressor pathway. J Clin Oncol 22:2954-63
Hsieh, Andrew C; Bo, Ronghai; Manola, Judith et al. (2004) A library of siRNA duplexes targeting the phosphoinositide 3-kinase pathway: determinants of gene silencing for use in cell-based screens. Nucleic Acids Res 32:893-901
Kau, Tweeny R; Schroeder, Frank; Ramaswamy, Shivapriya et al. (2003) A chemical genetic screen identifies inhibitors of regulated nuclear export of a Forkhead transcription factor in PTEN-deficient tumor cells. Cancer Cell 4:463-76
Ramaswamy, Shivapriya; Nakamura, Noriaki; Sansal, Isabelle et al. (2002) A novel mechanism of gene regulation and tumor suppression by the transcription factor FKHR. Cancer Cell 2:81-91
Nakamura, N; Ramaswamy, S; Vazquez, F et al. (2000) Forkhead transcription factors are critical effectors of cell death and cell cycle arrest downstream of PTEN. Mol Cell Biol 20:8969-82