Intratumoral therapies of prostate cancer include the delivery of brachytherapy or ablation energy sources, and adenoviral injection, through a minimally invasive, transperineal approach. They require quantitative, optimized treatment planning, precise placement of the needles/probes according to the treatment plan, and real time dosimetric evaluation in the operating room as deviations from the treatment plan are detected. Recent studies suggest that imprecisions in standard brachytherapy using the manual technique cause higher than previously appreciated complication rates, and may be the cause of local failure in 15% of the patients. The major goal of the proposed work is to develop the Robot-Assisted Platform for Intratumoral Delivery (RAPID) for integrated treatment of prostate cancer, and to demonstrate the safety, efficacy and clinical effectiveness through bench/phantom tests and a Phase I clinical study. A number of maturing component technologies previously developed by the bioengineering research partners will be combined in this major collaboration, including the first robotic system for urological applications with early experience on actual patient treatment, the first treatment planning system with intraoperative dosimetry optimization, and the first needle/probe tracking system for real time ultrasound-based treatment verification, permitting re-planning and re-optimization of therapy delivery. The integrated RAPID system, designed based on prototype subsystems developed at each of the research partners, will initially focus on interstitial brachytherapy of prostate cancer. It is aimed at delivering precise, non-coplanar 3D conformal radiation rapidly and with assured consistency, and to incorporate such complex concurrent therapies as radiosensitization and mixed agent/strengths brachytherapy. Primary outcome variables including implant quality, cost, morbidity and learning curve will be examined under the clinical study by comparison with historical controls. The long-term objective of the RAPID project is to incorporate the delivery of concomitant therapeutic agents intratumorally for cancer in the prostate as well as in other organ systems. The multi-agent, multi-modality capabilities of the RAPID system will be continually exploited towards total optimization of a turnkey in vivo diagnosis and therapy engine for localized cancers of solid organs.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA091763-02
Application #
6802281
Study Section
Special Emphasis Panel (ZRG1-RAD (04))
Program Officer
Deye, James
Project Start
2003-09-01
Project End
2008-08-31
Budget Start
2004-09-01
Budget End
2005-08-31
Support Year
2
Fiscal Year
2004
Total Cost
$616,958
Indirect Cost
Name
University of Rochester
Department
Radiation-Diagnostic/Oncology
Type
Schools of Dentistry
DUNS #
041294109
City
Rochester
State
NY
Country
United States
Zip Code
14627
Podder, Tarun K; Buzurovic, Ivan; Huang, Ke et al. (2011) Reliability of EUCLIDIAN: an autonomous robotic system for image-guided prostate brachytherapy. Med Phys 38:96-106
Yan, K; Podder, T; Li, L et al. (2009) A real-time prostate cancer detection technique using needle insertion force and patient-specific criteria during percutaneous intervention. Med Phys 36:4184-90
Yan, K; Li, L; Joseph, J et al. (2009) A real-time prostate cancer detection technique using needle insertion force and patient-specific criteria during percutaneous intervention. Med Phys 36:3356-62
Yan, Kai Guo; Podder, Tarun; Yu, Yan et al. (2009) Flexible needle-tissue interaction modeling with depth-varying mean parameter: preliminary study. IEEE Trans Biomed Eng 56:255-62
Podder, Tarun; Sherman, Jason; Rubens, Deborah et al. (2008) Methods for prostate stabilization during transperineal LDR brachytherapy. Phys Med Biol 53:1563-79
Yan, Kaiguo; Podder, Tarun; Ng, Wan Sing et al. (2007) 'Smart'needle for percutaneous surgery: influential factor investigation. Conf Proc IEEE Eng Med Biol Soc 2007:461-4
Hu, Yida; Podder, Tarun; Buzurovic, Ivan et al. (2007) Hazard analysis of EUCLIDIAN: an image-guided robotic brachytherapy system. Conf Proc IEEE Eng Med Biol Soc 2007:1249-52
Yu, Y; Podder, T K; Zhang, Y D et al. (2007) Robotic system for prostate brachytherapy. Comput Aided Surg 12:366-70
Yu, Yan; Podder, Tarun; Zhang, Yongde et al. (2006) Robot-assisted prostate brachytherapy. Med Image Comput Comput Assist Interv 9:41-9
Podder, T K; Sherman, J; Fuller, D et al. (2006) In-vivo measurement of surgical needle intervention parameters: a pilot study. Conf Proc IEEE Eng Med Biol Soc 1:3652-5

Showing the most recent 10 out of 16 publications