Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA091883-02
Application #
6697450
Study Section
Special Emphasis Panel (ZRG1-PTHB (02))
Program Officer
Parnes, Howard L
Project Start
2003-02-14
Project End
2007-12-31
Budget Start
2004-01-01
Budget End
2004-12-31
Support Year
2
Fiscal Year
2004
Total Cost
$341,538
Indirect Cost
Name
University of Colorado Denver
Department
Pharmacology
Type
Schools of Pharmacy
DUNS #
041096314
City
Aurora
State
CO
Country
United States
Zip Code
80045
Kumar, Rahul; Deep, Gagan; Wempe, Michael F et al. (2018) Procyanidin B2 3,3?-di-O-gallate induces oxidative stress-mediated cell death in prostate cancer cells via inhibiting MAP kinase phosphatase activity and activating ERK1/2 and AMPK. Mol Carcinog 57:57-69
Reed, Dominique; Raina, Komal; Agarwal, Rajesh (2018) Nutraceuticals in prostate cancer therapeutic strategies and their neo-adjuvant use in diverse populations. NPJ Precis Oncol 2:15
Shrotriya, Sangeeta; Tyagi, Alpna; Deep, Gagan et al. (2015) Grape seed extract and resveratrol prevent 4-nitroquinoline 1-oxide induced oral tumorigenesis in mice by modulating AMPK activation and associated biological responses. Mol Carcinog 54:291-300
Kumar, Rahul; Deep, Gagan; Wempe, Michael F et al. (2015) Procyanidin B2 3,3?-di-O-gallate inhibits endothelial cells growth and motility by targeting VEGFR2 and integrin signaling pathways. Curr Cancer Drug Targets 15:14-26
Shrotriya, Sangeeta; Deep, Gagan; Lopert, Pamela et al. (2015) Grape seed extract targets mitochondrial electron transport chain complex III and induces oxidative and metabolic stress leading to cytoprotective autophagy and apoptotic death in human head and neck cancer cells. Mol Carcinog 54:1734-47
Tyagi, Alpna; Raina, Komal; Shrestha, Suraj Prakash et al. (2014) Procyanidin B2 3,3(?)-di-O-gallate, a biologically active constituent of grape seed extract, induces apoptosis in human prostate cancer cells via targeting NF-?B, Stat3, and AP1 transcription factors. Nutr Cancer 66:736-46
Ting, Harold; Deep, Gagan; Agarwal, Chapla et al. (2014) The strategies to control prostate cancer by chemoprevention approaches. Mutat Res 760:1-15
Tyagi, Alpna; Raina, Komal; Gangar, Subhash et al. (2013) Differential effect of grape seed extract against human non-small-cell lung cancer cells: the role of reactive oxygen species and apoptosis induction. Nutr Cancer 65 Suppl 1:44-53
Raina, Komal; Tyagi, Alpna; Kumar, Dileep et al. (2013) Role of oxidative stress in cytotoxicity of grape seed extract in human bladder cancer cells. Food Chem Toxicol 61:187-95
Shrotriya, Sangeeta; Gagan, Deep; Ramasamy, Kumaraguruparan et al. (2012) Poly[3-(3, 4-dihydroxyphenyl) glyceric acid] from Comfrey exerts anti-cancer efficacy against human prostate cancer via targeting androgen receptor, cell cycle arrest and apoptosis. Carcinogenesis 33:1572-80

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