? Broad long-term objectives: To develop methods of assessing angiogenesis in brain tumors using dynamic, contrast enhanced perfusion MRI (pMRI). Health-relatedness: The project will apply pMRI to the evaluation of brain tumors undergoing antioangiogenic and other chemotherapeutic treatments. However, the developed methods will also be useful in evaluating neoplastic lesions outside the brain and non-neoplastic lesions within it.
Specific aims : 1) To investigate the hypothesis that pMRI measurements of cerebral blood volume (CBV) and vascular permeability correlate with histological assessments of vascularity and blood-brain barrier (BBB) breakdown respectively. 2) To determine whether pMRI can be used to grade brain tumors. 3) To investigate the hypothesis that pMRI can be used to monitor the efficacy of chemotherapeutic treatments. Research design: 1) Murine gliomas will be imaged with pMRI on a 7T animal imager. MRI measurements of CBV and vascular permeability will be correlated with histological assessments of vascular density and Evan's blue extravasation respectively. 2) CBV and vascular permeability will be measured in patients with histologically confirmed brain tumors of different grades to determine whether these measurements differentiate between them. 3) Serial pMRI measurements will be made on glioma patients enrolled in trials of new chemotherapeutic agents: thalidomide combined with carboplatin and the alkylating agents temodar and CPT-11. MRI measurements will be correlated with tumor size and clinical outcome to determine whether pMRI indications of angiogenesis predict tumor recurrence. ? ?

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA093992-03
Application #
6937100
Study Section
Diagnostic Radiology Study Section (RNM)
Program Officer
Liu, Guoying
Project Start
2003-07-01
Project End
2008-04-30
Budget Start
2005-07-29
Budget End
2006-04-30
Support Year
3
Fiscal Year
2005
Total Cost
$376,025
Indirect Cost
Name
New York University
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
121911077
City
New York
State
NY
Country
United States
Zip Code
10016
Patil, Vishal; Jensen, Jens H; Johnson, Glyn (2012) Intravascular contrast agent T(2) (*) relaxivity in brain tissue. NMR Biomed :
Patil, Vishal; Johnson, Glyn; Jensen, Jens H (2009) Robust quantification of contrast agent (CA) concentration with magnetic field correlation (MFC) imaging. Magn Reson Med 62:1002-6
Lu, H; Pollack, E; Young, R et al. (2008) Predicting grade of cerebral glioma using vascular-space occupancy MR imaging. AJNR Am J Neuroradiol 29:373-8
Law, Meng; Young, Robert J; Babb, James S et al. (2008) Gliomas: predicting time to progression or survival with cerebral blood volume measurements at dynamic susceptibility-weighted contrast-enhanced perfusion MR imaging. Radiology 247:490-8
Lui, Yvonne W; Law, Meng; Chacko-Mathew, Jeena et al. (2007) Brainstem corticospinal tract diffusion tensor imaging in patients with primary posterior fossa neoplasms stratified by tumor type: a study of association with motor weakness and outcome. Neurosurgery 61:1199-207;discussion 1207-8
Young, Robert; Babb, James; Law, Meng et al. (2007) Comparison of region-of-interest analysis with three different histogram analysis methods in the determination of perfusion metrics in patients with brain gliomas. J Magn Reson Imaging 26:1053-63
Law, M; Young, R; Babb, J et al. (2007) Histogram analysis versus region of interest analysis of dynamic susceptibility contrast perfusion MR imaging data in the grading of cerebral gliomas. AJNR Am J Neuroradiol 28:761-6
Law, Meng; Brodsky, Jennie E; Babb, James et al. (2007) High cerebral blood volume in human gliomas predicts deletion of chromosome 1p: Preliminary results of molecular studies in gliomas with elevated perfusion. J Magn Reson Imaging 25:1113-9
Law, Meng; Oh, Sarah; Babb, James S et al. (2006) Low-grade gliomas: dynamic susceptibility-weighted contrast-enhanced perfusion MR imaging--prediction of patient clinical response. Radiology 238:658-67
Law, M; Young, R; Babb, J et al. (2006) Comparing perfusion metrics obtained from a single compartment versus pharmacokinetic modeling methods using dynamic susceptibility contrast-enhanced perfusion MR imaging with glioma grade. AJNR Am J Neuroradiol 27:1975-82

Showing the most recent 10 out of 17 publications