Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA094922-02
Application #
6694024
Study Section
Experimental Immunology Study Section (EI)
Program Officer
Mccarthy, Susan A
Project Start
2003-01-01
Project End
2007-12-31
Budget Start
2004-01-01
Budget End
2004-12-31
Support Year
2
Fiscal Year
2004
Total Cost
$266,466
Indirect Cost
Name
Pennsylvania State University
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
129348186
City
Hershey
State
PA
Country
United States
Zip Code
17033
Sun, Shao-Cong; Chang, Jae-Hoon; Jin, Jin (2013) Regulation of nuclear factor-?B in autoimmunity. Trends Immunol 34:282-9
Zhang, Minying; Wu, Xuefeng; Lee, Andrew J et al. (2008) Regulation of IkappaB kinase-related kinases and antiviral responses by tumor suppressor CYLD. J Biol Chem 283:18621-6
Sun, Shao-Cong; Ley, Steven C (2008) New insights into NF-kappaB regulation and function. Trends Immunol 29:469-78
Sun, Shao-Cong (2008) Deubiquitylation and regulation of the immune response. Nat Rev Immunol 8:501-11
Jin, Wei; Chang, Mikyoung; Paul, Emmanuel M et al. (2008) Deubiquitinating enzyme CYLD negatively regulates RANK signaling and osteoclastogenesis in mice. J Clin Invest 118:1858-66
Wright, Ato; Reiley, William W; Chang, Mikyoung et al. (2007) Regulation of early wave of germ cell apoptosis and spermatogenesis by deubiquitinating enzyme CYLD. Dev Cell 13:705-16
Wu, Xuefeng; Sun, Shao-Cong (2007) Retroviral oncoprotein Tax deregulates NF-kappaB by activating Tak1 and mediating the physical association of Tak1-IKK. EMBO Rep 8:510-5
Reiley, William W; Jin, Wei; Lee, Andrew Joon et al. (2007) Deubiquitinating enzyme CYLD negatively regulates the ubiquitin-dependent kinase Tak1 and prevents abnormal T cell responses. J Exp Med 204:1475-85
Jin, Wei; Reiley, William R; Lee, Andrew J et al. (2007) Deubiquitinating enzyme CYLD regulates the peripheral development and naive phenotype maintenance of B cells. J Biol Chem 282:15884-93
Reiley, William W; Zhang, Minying; Jin, Wei et al. (2006) Regulation of T cell development by the deubiquitinating enzyme CYLD. Nat Immunol 7:411-7

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