Polychlorinated biphenyls (PCBs) and 2,3,7,8-tetrachlorinated dibenzo-dioxin (TCDD) are neurodevelopmental and immunologic toxicants in experimental animals treated prenatally. Associations with neurobehavioural deficits are found in some but not all epidemiologic studies of environmental exposures, with data suggesting the prenatal period to be the most sensitive. Additionally, the risk of intrauterine growth retardation increases with higher environmental PCB exposures, and several reports suggest a more potent effect in male babies. The proposed study will therefore evaluate prenatal and postnatal PCB and dioxin exposures in relation to immune markers at birth and in early childhood, to intrauterine and early childhood growth, and to early neurobehavioral development. It will be conducted in the Slovak Republic, where a chemical plant that manufactured PCBs improperly discharged large quantitites of contaminated waste into the surrounding area. A total of 1200 births in years 2001-2003 will be enrolled in two districts, half from the district with high contamination of PCBs, and the other half from a district with lower contamination levels. The study will parallel a European Union-funded study of adults and school-age children in the same two districts. The project will be one of the first to evaluate a wide battery of immune parameters in an epidemiologic study, including lymphocyte immunophenotypes, thymic size, post-vaccination antibody titers, aand morbidity. It will also be the largest to-dat to evlaute neurobehavioral development. Other unique features include the evaluation of hearing loss at birth, the measurement of hydroxy and methylsulfone metabolites of PCBs, and a population which includes about 1/3 Gypsies.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA096525-02
Application #
6522950
Study Section
Special Emphasis Panel (ZOH1-PCM (01))
Program Officer
Verma, Mukesh
Project Start
2001-09-30
Project End
2005-08-31
Budget Start
2002-09-01
Budget End
2003-08-31
Support Year
2
Fiscal Year
2002
Total Cost
$578,954
Indirect Cost
Name
University of California Davis
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
094878337
City
Davis
State
CA
Country
United States
Zip Code
95618
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Santos, Susana; Eekhout, Iris; Voerman, Ellis et al. (2018) Gestational weight gain charts for different body mass index groups for women in Europe, North America, and Oceania. BMC Med 16:201
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Palkovi?ová Murínová, ?ubica; Moleti, Arturo; Sisto, Renata et al. (2016) PCB exposure and cochlear function at age 6 years. Environ Res 151:428-435
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Jusko, Todd A; Oktapodas, Marina; Palkovi?ová Murinová, L'ubica et al. (2016) Demographic, Reproductive, and Dietary Determinants of Perfluorooctane Sulfonic (PFOS) and Perfluorooctanoic Acid (PFOA) Concentrations in Human Colostrum. Environ Sci Technol 50:7152-62
Lancz, Kinga; Murínová, Lubica; Patayová, Henrieta et al. (2015) Ratio of cord to maternal serum PCB concentrations in relation to their congener-specific physicochemical properties. Int J Hyg Environ Health 218:91-8
Wimmerová, So?a; Watson, Alan; Drobná, Beata et al. (2015) The spatial distribution of human exposure to PCBs around a former production site in Slovakia. Environ Sci Pollut Res Int 22:14405-15

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