The overall goal of this proposal is to develop a hybrid, dual-modality x-ray computed tomography (XCT) and single photon emission computed tomography (SPECT) scanner for dedicated breast and axillary imaging, termed application specific emission and transmission tomography (ASETT). This noninvasive imaging tool is intended to provide volumetric, co-registered anatomical and functional imaging data for improved diagnosis of breast cancer. The XCT component of the system can provide structural three-dimensional images of the breast and axillary region with exposure near that of dual-view screening mammography, greatly improving the detectability of low contrast lesions in the breast, enhancing the spatially-dependent attenuation correction of the SPECT data, and facilitating better interpretation and quantification of the SPECT data by objectively guiding region of interest selection. This proposal represents the initial technology development for a dedicated breast ASETT system. A prototype, dedicated SPECT scanner has previously been investigated, and a gantry has been developed that facilitates a new class of hemispherical acquisition orbits about a pendant breast. This proposal will (1) extend the capabilities and performance characteristics of the SPECT camera and gantry, (2) develop and optimize the dedicated XCT scanner, and (3) integrate the two into a single system. The new SPECT system will have improved intrinsic spatial resolution (4.5mm) and intrinsic energy resolution (10% FWHM), and an expanded field-of-view, with fully computer controllable degrees of freedom. The XCT system will incorporate a novel x-ray source/filtration approach to mammographic imaging with a pseudo- monochromatic beam and a state-of-the-art, flat-panel, scintillator-based digital detector to reach <1mm isotropic reconstructed resolution. The ASETT detector system will be characterized and optimized for tomographic breast and axillary imaging. Novel orbits to sufficiently sample the pendant breast and axillary region will be developed, and trade-offs between sequential or simultaneous XCT/SPECT imaging, resolution, signal-to-noise, and radiation dose to the breast volume will be investigated. Appropriate phantoms will be used to quantitatively assess image quality and dose. Finally, the dual-modality ASETT system will be clinically evaluated with pilot patient studies.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA096821-03
Application #
6802353
Study Section
Special Emphasis Panel (ZRG1-RNM (33))
Program Officer
Farahani, Keyvan
Project Start
2002-09-19
Project End
2007-08-31
Budget Start
2004-09-01
Budget End
2005-08-31
Support Year
3
Fiscal Year
2004
Total Cost
$474,660
Indirect Cost
Name
Duke University
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
Shah, Jainil P; Mann, Steve D; McKinley, Randolph L et al. (2018) Characterization of CT Hounsfield Units for 3D acquisition trajectories on a dedicated breast CT system. J Xray Sci Technol 26:535-551
Shah, Jainil P; Mann, Steve D; Tornai, Martin P (2017) Characterization of X-ray scattering for various phantoms and clinical breast geometries using breast CT on a dedicated hybrid system. J Xray Sci Technol 25:373-389
Shah, Jainil P; Mann, Steve D; McKinley, Randolph L et al. (2017) Implementation and CT sampling characterization of a third-generation SPECT-CT system for dedicated breast imaging. J Med Imaging (Bellingham) 4:033502
Mann, Steve D; Tornai, Martin P (2015) Characterization of simulated incident scatter and the impact on quantification in dedicated breast single-photon emission computed tomography. J Med Imaging (Bellingham) 2:033504
Shah, Jainil P; Mann, Steve D; McKinley, Randolph L et al. (2015) Three dimensional dose distribution comparison of simple and complex acquisition trajectories in dedicated breast CT. Med Phys 42:4497-510
MacCabe, Kenneth P; Holmgren, Andrew D; Tornai, Martin P et al. (2013) Snapshot 2D tomography via coded aperture x-ray scatter imaging. Appl Opt 52:4582-9
Mann, Steve D; Perez, Kristy L; McCracken, Emily K E et al. (2012) Initial In Vivo Quantification of Tc-99m Sestamibi Uptake as a Function of Tissue Type in Healthy Breasts Using Dedicated Breast SPECT-CT. J Oncol 2012:146943
Shinnar, Shlomo; Bello, Jacqueline A; Chan, Stephen et al. (2012) MRI abnormalities following febrile status epilepticus in children: the FEBSTAT study. Neurology 79:871-7
Pachon, Jan H; Shah, Jainil; Tornai, Martin P (2011) Characterization of Image Quality for 3D Scatter Corrected Breast CT Images. Proc SPIE Int Soc Opt Eng 7961:
Shah, Jainil; Pachon, Jan H; Madhav, Priti et al. (2011) Detailed Characterization of 2D and 3D Scatter-to-Primary Ratios of Various Breast Geometries Using a Dedicated CT Mammotomography System. Proc SPIE Int Soc Opt Eng 7961:

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