Skin cancer, the most common cancer in the U.S., is more prevalent than all other malignancies combined. Basal cell carcinoma (BCC), the most common form of human cancer, shows evidence for spontaneous regression in approximately 44% of the tumors. Importantly, both spontaneous regression of tumors and appearance of new tumors appear to be related to the immune response to the tumor. Focusing on the microenvironment within BCC tumors, this study addresses the interplay between psychological factors and immune function, and how this interplay may be related to immune/molecular markers associated with histopathological characteristics of BCC tumors that are relatively higher or lower in their immunoreactivity. We will recruit 320 patients who have recently had a BCC removed (the """"""""index"""""""" tumor). Two pathologists will evaluate the tumors and assess their immunoreactivity as measured by the level of immune cells trafficking to the tumor and the expression of immune and apoptotic markers expressed by these cells; they will also determine the tumor subtype. We will evaluate cross-sectional relationships between the immunogenic status of the BCC tumors and the influence of age, gender, severe life stressors, and depressive symptoms. Accordingly, we have the following specific aims: 1) Using the index BCC, we will determine if depressive symptoms and severe life stressors are related to markers shown to be reflective of immunoreactivity to a BCC, i.e., tumors showing differences in the level of CD3+ and CD68+ cells that traffic to the BCC tumor and surrounding stroma (quantitative measures) and the expression of cell markers, including CD25, ICAM-1, IFN-7, and IL-10, reflecting the activation of these cells (qualitative measures) and bcl-2, an apoptosis marker associated with tumor regression. 2) We will determine if the relationships between depressive symptoms and severe life stressors and tumor immunoreactivity are more pronounced among older adults.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
3R01CA100243-03S1
Application #
7409508
Study Section
Biobehavioral Mechanisms of Emotion, Stress and Health Study Section (MESH)
Program Officer
Ogunbiyi, Peter
Project Start
2005-03-16
Project End
2008-02-28
Budget Start
2007-03-01
Budget End
2008-02-28
Support Year
3
Fiscal Year
2007
Total Cost
$198,714
Indirect Cost
Name
Ohio State University
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
832127323
City
Columbus
State
OH
Country
United States
Zip Code
43210
Hosang, Georgina M; Johnson, Sheri L; Kiecolt-Glaser, Janice et al. (2013) Gender specific association of child abuse and adult cardiovascular disease in a sample of patients with basal cell carcinoma. Child Abuse Negl 37:374-9
Fagundes, Christopher P; Glaser, Ronald; Johnson, Sheri L et al. (2012) Basal cell carcinoma: stressful life events and the tumor environment. Arch Gen Psychiatry 69:618-26
Glaser, Ronald; Andridge, Rebecca; Yang, Eric V et al. (2011) Tumor site immune markers associated with risk for subsequent basal cell carcinomas. PLoS One 6:e25160
Lemeshow, Stanley; Sørensen, Henrik Toft; Phillips, Gary et al. (2011) ?-Blockers and survival among Danish patients with malignant melanoma: a population-based cohort study. Cancer Epidemiol Biomarkers Prev 20:2273-9
Yang, Eric V (2010) Role for catecholamines in tumor progression: possible use for ?-blockers in the treatment of cancer. Cancer Biol Ther 10:30-2
Yang, Eric V; Webster Marketon, Jeanette I; Chen, Min et al. (2010) Glucocorticoids activate Epstein Barr virus lytic replication through the upregulation of immediate early BZLF1 gene expression. Brain Behav Immun 24:1089-96
Yang, Eric V; Kim, Seung-jae; Donovan, Elise L et al. (2009) Norepinephrine upregulates VEGF, IL-8, and IL-6 expression in human melanoma tumor cell lines: implications for stress-related enhancement of tumor progression. Brain Behav Immun 23:267-75
Yang, Eric V; Donovan, Elise L; Benson, Don M et al. (2008) VEGF is differentially regulated in multiple myeloma-derived cell lines by norepinephrine. Brain Behav Immun 22:318-23
Stowe, Raymond P; Kozlova, Elena V; Yetman, Deborah L et al. (2007) Chronic herpesvirus reactivation occurs in aging. Exp Gerontol 42:563-70
Graham, Jennifer E; Christian, Lisa M; Kiecolt-Glaser, Janice K (2006) Stress, age, and immune function: toward a lifespan approach. J Behav Med 29:389-400

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