The rising popularity of indoor tanning, an artificial source of ultraviolet radiation (UV) raises concerns that the melanoma epidemic will continue to cause unnecessary morbidity and mortality. Most epidemiologic studies of this risk factor and melanoma predate the introduction of modern tanning equipment (ca 1980), thus new epidemiologic studies are urgently needed among individuals with substantial levels of exposure and collection of detailed exposure information. In addition, our understanding of the role of DNA repair in modifying the risks of melanoma associated with UV exposure is just emerging.
The specific aims of our proposal are to assess whether frequent and/or long-term use of modern era indoor tanning increases the risk of melanoma, and whether the risk of melanoma may be influenced by variation in inherited polymorphisms that affect DNA repair. We propose to conduct a population-based case-control study of melanoma among 2660 residents of Minnesota (1330 cases, 1330 controls), ages 25-59, a group found to have a high prevalence of exposure to indoor tanning. We will identify cases through the Minnesota Cancer Surveillance System, a pathology-based, statewide cancer registry of high quality and completeness for case ascertainment. Each case and control subject's history of exposure to indoor tanning, and to potential confounders will be collected during a telephone interview. Buccal cell samples from cases and controls will be collected for DNA. Associations between indoor tanning or impaired capacity to repair DNA and melanoma will be measured by the odds ratio, controlling for known confounders. Differences in risk of melanoma associated with exposure to solar or artificial ultraviolet radiation will be explored by skin type and by DNA repair pathways specific to the repair of UVB- or UVA-induced DNA damage in skin. Except for sun exposure, established risk factors for melanoma, such as skin type or family history, are not amenable to change. Indoor tanning behavior, however, is under the control of the individual. If well-designed epidemiologic studies confirm that indoor tanning is a risk factor for melanoma and that some individuals are particularly susceptible to its effects, public health action may be indicated to discourage use and reduce the risk of the melanoma.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
1R01CA106807-01A1
Application #
6873303
Study Section
Epidemiology of Cancer Study Section (EPIC)
Program Officer
Verma, Mukesh
Project Start
2004-09-30
Project End
2009-08-31
Budget Start
2004-09-30
Budget End
2005-08-31
Support Year
1
Fiscal Year
2004
Total Cost
$574,349
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
555917996
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Vogel, Rachel Isaksson; Strayer, Lori G; Engelman, Leah et al. (2017) Comparison of quality of life among long-term melanoma survivors and non-melanoma controls: a cross-sectional study. Qual Life Res 26:1761-1766
Lazovich, DeAnn; Isaksson Vogel, Rachel; Weinstock, Martin A et al. (2016) Association Between Indoor Tanning and Melanoma in Younger Men and Women. JAMA Dermatol 152:268-75
Vogel, Rachel Isaksson; Ahmed, Rehana L; Nelson, Heather H et al. (2014) Exposure to indoor tanning without burning and melanoma risk by sunburn history. J Natl Cancer Inst 106:
Penn, Lauren A; Qian, Meng; Zhang, Enhan et al. (2014) Development of a melanoma risk prediction model incorporating MC1R genotype and indoor tanning exposure: impact of mole phenotype on model performance. PLoS One 9:e101507
Ferrucci, Leah M; Vogel, Rachel Isaksson; Cartmel, Brenda et al. (2014) Indoor tanning in businesses and homes and risk of melanoma and nonmelanoma skin cancer in 2 US case-control studies. J Am Acad Dermatol 71:882-7
Vogel, Rachel Isaksson; Ahmed, Rehana L; Nelson, Heather H et al. (2014) Exposure to indoor tanning without burning and melanoma risk by sunburn history. J Natl Cancer Inst 106:dju112
Flores, Kristina G; Erdei, Esther; Luo, Li et al. (2013) A pilot study of genetic variants in dopamine regulators with indoor tanning and melanoma. Exp Dermatol 22:576-81
Torres, Salina M; Luo, Li; Lilyquist, Jenna et al. (2013) DNA repair variants, indoor tanning, and risk of melanoma. Pigment Cell Melanoma Res 26:677-84
Lazovich, Deann; Vogel, Rachel Isaksson; Berwick, Marianne et al. (2011) Melanoma risk in relation to use of sunscreen or other sun protection methods. Cancer Epidemiol Biomarkers Prev 20:2583-93
Nunes, Anthony P; Lapane, Kate L; Weinstock, Martin A et al. (2011) Association between non-steroidal anti-inflammatory drugs and keratinocyte carcinomas of the skin among participants in the Veterans Affairs Topical Tretinoin Chemoprevention Trial. Pharmacoepidemiol Drug Saf 20:922-9

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