Image guidance of cancer ablation procedures of the liver and other organs would ideally utilize a modality capable of visualizing normal anatomic structures, the ablation electrode, the cancerous lesion, and the growing thermal lesion. When, as frequently occurs, ultrasonic methods prove inadequate in viewing the tumor, CT with and without fluoroscopic imaging, and, in very few institutions, MRI are often used to guide placement of the ablation electrode. None of these methods are both practical and successful in accurately displaying the ablated tissue during the ablation procedure with the result that, currently, liver ablations are performed in a largely """"""""blinded"""""""" fashion. MR or CT imaging, especially during the catheter placement attempts, increases the length and cost of ablation procedures and limits the number of sites than can be practically ablated. However, MR, CT, and PET imaging remain the gold standard for assessment of ablation outcomes and imaging of potential tumor regrowth. We have developed a novel ultrasonic imaging method, Acoustic Radiation Force Impulse (ARFI) imaging, which shows great promise in real-time visualization of growing ablation lesions and, we hypothesize, will allow improved imaging of cancerous lesions in the liver. Significant challenges remain in developing ARFI imaging as an ablation guidance method and in optimizing and assessing its clinical relevance.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA114093-04
Application #
7417450
Study Section
Special Emphasis Panel (ZRG1-SBIB-F (02))
Program Officer
Farahani, Keyvan
Project Start
2005-05-01
Project End
2010-03-31
Budget Start
2008-04-01
Budget End
2009-03-31
Support Year
4
Fiscal Year
2008
Total Cost
$288,390
Indirect Cost
Name
Duke University
Department
Biomedical Engineering
Type
Schools of Engineering
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
Lediju Bell, Muyinatu A; Dahl, Jeremy J; Trahey, Gregg E (2015) Resolution and brightness characteristics of short-lag spatial coherence (SLSC) images. IEEE Trans Ultrason Ferroelectr Freq Control 62:1265-76
Dahl, Jeremy; Jakovljevic, Marko; Pinton, Gianmarco F et al. (2012) Harmonic spatial coherence imaging: an ultrasonic imaging method based on backscatter coherence. IEEE Trans Ultrason Ferroelectr Freq Control 59:648-59
Dahl, Jeremy J; Hyun, Dongwoon; Lediju, Muyinatu et al. (2011) Lesion detectability in diagnostic ultrasound with short-lag spatial coherence imaging. Ultrason Imaging 33:119-33
Pinton, Gianmarco F; Trahey, Gregg E; Dahl, Jeremy J (2011) Sources of image degradation in fundamental and harmonic ultrasound imaging using nonlinear, full-wave simulations. IEEE Trans Ultrason Ferroelectr Freq Control 58:754-65
Lediju, Muyinatu A; Trahey, Gregg E; Byram, Brett C et al. (2011) Short-lag spatial coherence of backscattered echoes: imaging characteristics. IEEE Trans Ultrason Ferroelectr Freq Control 58:1377-88
Pinton, Gianmarco F; Trahey, Gregg E; Dahl, Jeremy J (2011) Sources of image degradation in fundamental and harmonic ultrasound imaging: a nonlinear, full-wave, simulation study. IEEE Trans Ultrason Ferroelectr Freq Control 58:1272-83
Lediju, Muyinatu A; Pihl, Michael J; Hsu, Stephen J et al. (2009) A motion-based approach to abdominal clutter reduction. IEEE Trans Ultrason Ferroelectr Freq Control 56:2437-49
Dahl, Jeremy J; Dumont, Douglas M; Allen, Jason D et al. (2009) Acoustic radiation force impulse imaging for noninvasive characterization of carotid artery atherosclerotic plaques: a feasibility study. Ultrasound Med Biol 35:707-16
Pinton, Gianmarco F; Dahl, Jeremy; Rosenzweig, Stephen et al. (2009) A heterogeneous nonlinear attenuating full-wave model of ultrasound. IEEE Trans Ultrason Ferroelectr Freq Control 56:474-88
Hsu, Stephen J; Bouchard, Richard R; Dumont, Douglas M et al. (2009) Novel acoustic radiation force impulse imaging methods for visualization of rapidly moving tissue. Ultrason Imaging 31:183-200

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