Cancer is predicted to be the leading cause of death in 2010 and with 1.5 million newly diagnosed cases for this year alone, cancer survivors are becoming an increasingly large part of the US population. Patient- reported outcomes (PROs) instruments of health-related quality of life (HRQoL) can capture the experiences of cancer patients, and are increasingly used in clinical trials and other forms of comparative effectiveness research (CER) to characterize decision-relevant health outcomes. The NIH Patient-Reported Outcomes Measurement Information System (PROMIS) Network has developed standardized, valid, and precise PROs measures for CER. While these tools provide domain-specific scores, scores alone do not express the value or importance of specific domains or summarize HRQoL across domains from the perspective of cancer patients. Thus, there is a need to facilitate CER by translating PROMIS PROs into decision-relevant health outcome values. In the proposed study, we will recruit members of the general public and cancer survivors (breast, prostate, colorectal) to complete a discrete choice experiment (DCE) to value PROMIS-29 outcomes. The PROMIS-29 instrument includes 7 HRQoL scales (physical function, pain interference, fatigue, depression, anxiety, sleep disturbance, and social role-participation) measured by 4 items/questions each, and a pain intensity scale measured by a single item.
Specific aims of the project are (1) to value PROMIS-29 outcomes from a societal perspective, and (2) to value PROMIS-29 outcomes from a cancer survivor perspective. By aggregating HRQoL domains into decision-relevant values from a societal and cancer survivor perspective, CER can better differentiate treatment outcomes and enhance the translation of its findings to clinical practice. Since living with cancer may alter a person's values for HRQoL outcomes, discrepancies between cancer survivor and general public values must be understood and accounted for in CER, patient-centered decision- making, and public health resource allocation. Although the general public is considered the central stakeholder for CER and allocation of public resources, the values of experienced patients may better inform prospective patients of the burden associated with cancer therapies. Incorporating these values with PROs in CER can help NIH achieve its goal of improving the Nation's health and economic well-being by increasing the availability of decision-relevant information that can be applied at the patient and societal level.

Public Health Relevance

Sponsored by the National Institutes of Health (NIH), the Patient-Reported Outcomes Measurement Information System (PROMIS) has developed standardized patient-reported outcome (PRO) measures that assess health-related quality of life (such as pain or fatigue);however, these measures do not reflect the importance or value people place on specific health outcomes. By translating PROMIS PROs into health values, the proposed study will enhance comparative effectiveness research and improve medical-decision making by incorporating the values of cancer survivors and the general public.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA160104-02
Application #
8330753
Study Section
Special Emphasis Panel (ZRG1-AARR-F (52))
Program Officer
Clauser, Steven
Project Start
2011-09-09
Project End
2016-07-31
Budget Start
2012-08-01
Budget End
2013-07-31
Support Year
2
Fiscal Year
2012
Total Cost
$609,539
Indirect Cost
$188,086
Name
H. Lee Moffitt Cancer Center & Research Institute
Department
Type
DUNS #
139301956
City
Tampa
State
FL
Country
United States
Zip Code
33612
Craig, Benjamin M; Greiner, Wolfgang; Brown, Derek S et al. (2016) Valuation of Child Health-Related Quality of Life in the United States. Health Econ 25:768-77
Craig, Benjamin M; Hartman, John D; Owens, Michelle A et al. (2016) Prevalence and Losses in Quality-Adjusted Life Years of Child Health Conditions: A Burden of Disease Analysis. Matern Child Health J 20:862-9
Craig, Benjamin M; Brown, Derek S; Reeve, Bryce B (2016) Valuation of Child Behavioral Problems from the Perspective of US Adults. Med Decis Making 36:199-209
Craig, Benjamin M; Pickard, A Simon; Rand-Hendriksen, Kim (2015) Do health preferences contradict ordering of EQ-5D labels? Qual Life Res 24:1759-65
Craig, Benjamin M; Runge, Shannon K; Rand-Hendriksen, Kim et al. (2015) Learning and satisficing: an analysis of sequence effects in health valuation. Value Health 18:217-23
Craig, Benjamin M; Brown, Derek S; Reeve, Bryce B (2015) The Value Adults Place on Child Health and Functional Status. Value Health 18:449-56
Owens, Michelle A; Craig, Benjamin M; Egan, Kathleen M et al. (2015) Birth desires and intentions of women diagnosed with a meningioma. J Neurosurg 122:1151-6
Craig, Benjamin M; Reeve, Bryce B; Brown, Paul M et al. (2014) US valuation of health outcomes measured using the PROMIS-29. Value Health 17:846-53
Craig, Benjamin M; Reeve, Bryce B; Cella, David et al. (2014) Demographic differences in health preferences in the United States. Med Care 52:307-13
Craig, Benjamin M; Pickard, A Simon; Lubetkin, Erica I (2014) Health problems are more common, but less severe when measured using newer EQ-5D versions. J Clin Epidemiol 67:93-9

Showing the most recent 10 out of 15 publications