Abstract

There are limited quantitative methods to aid systematic design and development of drug delivery systems. We have developed a computational model that predicts the amount of drug that is delivered to the tumor, and we were able to make relevant predictions for ideal properties of liposomes from our models. The first goal of this grant application is the development of methods to measure tumor transport properties in vivo. The model is then validated, and will serve as platform for optimization of heat-activated liposomal carriers. The proposed approach thus aids the development of more effective drug delivery systems, and has general applicability for various drug delivery systems.

Public Health Relevance

The proposed work will result in computational models for design and testing of novel nanoparticles that deliver high amounts of chemotherapy to target areas. This project will aid the in design of advanced nanoparticle drug carriers that reduce side effects of current chemotherapies while improving drug delivery to tumors.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA181664-06
Application #
9765169
Study Section
Special Emphasis Panel (ZRG1)
Program Officer
Menkens, Anne E
Project Start
2014-09-25
Project End
2020-08-31
Budget Start
2019-09-01
Budget End
2020-08-31
Support Year
6
Fiscal Year
2019
Total Cost
Indirect Cost

  Institution

Name
Medical University of South Carolina
Department
Pediatrics
Type
Schools of Medicine
DUNS #
183710748
City
Charleston
State
SC
Country
United States
Zip Code
29407

  Publications

Burke, Caitlin; Dreher, Matthew R; Negussie, Ayele H et al. (2018) Drug release kinetics of temperature sensitive liposomes measured at high-temporal resolution with a millifluidic device. Int J Hyperthermia 34:786-794
Asemani, Davud; Haemmerich, Dieter (2018) A Unified Mathematical Model for Nano-Liposomal Drug Delivery to Solid Tumors. IEEE Trans Nanobioscience 17:3-11
Bredlau, Amy Lee; Motamarry, Anjan; Chen, Chao et al. (2018) Localized delivery of therapeutic doxorubicin dose across the canine blood-brain barrier with hyperthermia and temperature sensitive liposomes. Drug Deliv 25:973-984
Rossmann, Christian; McCrackin, M A; Armeson, Kent E et al. (2017) Temperature sensitive liposomes combined with thermal ablation: Effects of duration and timing of heating in mathematical models and in vivo. PLoS One 12:e0179131
Mikhail, Andrew S; Negussie, Ayele H; Pritchard, William F et al. (2017) Lyso-thermosensitive liposomal doxorubicin for treatment of bladder cancer. Int J Hyperthermia 33:733-740
Deshazer, Garron; Prakash, Punit; Merck, Derek et al. (2017) Experimental measurement of microwave ablation heating pattern and comparison to computer simulations. Int J Hyperthermia 33:74-82
Zalba, Sara; Ten Hagen, Timo L M (2017) Cell membrane modulation as adjuvant in cancer therapy. Cancer Treat Rev 52:48-57
Bredlau, A L; McCrackin, M A; Motamarry, Anjan et al. (2016) Thermal Therapy Approaches for Treatment of Brain Tumors in Animals and Humans. Crit Rev Biomed Eng 44:443-457
Swenson, Christine E; Haemmerich, Dieter; Maul, Donald H et al. (2015) Increased Duration of Heating Boosts Local Drug Deposition during Radiofrequency Ablation in Combination with Thermally Sensitive Liposomes (ThermoDox) in a Porcine Model. PLoS One 10:e0139752
Qi, Xiaoqiang; Li, Guangfu; Liu, Dai et al. (2015) Development of a radiofrequency ablation platform in a clinically relevant murine model of hepatocellular cancer. Cancer Biol Ther 16:1812-9

Showing the most recent 10 out of 12 publications