Abstract

This project will better define the pharmacogenetics of phencyclidine. In addition, the pharmacological factors involved in tolerance, dependence, withdrawal, and possible experimental treatments will be undertaken. The subjects of these studies will be purebred mice and outbred rats.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
5R01DA001531-08
Application #
3206943
Study Section
Drug Abuse Biomedical Research Review Committee (DABR)
Project Start
1979-09-01
Project End
1993-12-31
Budget Start
1992-09-01
Budget End
1993-12-31
Support Year
8
Fiscal Year
1992
Total Cost
Indirect Cost

  Institution

Name
University of Michigan Ann Arbor
Department
Type
Schools of Medicine
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109

  Publications

Xu, X; Domino, E F (1994) Phencyclidine-induced behavioral sensitization. Pharmacol Biochem Behav 47:603-8
Xu, X; Domino, E F (1994) Asymmetric cross-sensitization to the locomotor stimulant effects of phencyclidine and MK-801. Neurochem Int 25:155-9
Holsztynska, E J; Weber, W W; Domino, E F (1991) Genetic polymorphism of cytochrome P-450-dependent phencyclidine hydroxylation in mice. Comparison of phencyclidine hydroxylation in humans. Drug Metab Dispos 19:48-53
Pohorecki, R; Rayburn, W; Coon, W W et al. (1989) Some factors affecting phencyclidine biotransformation by human liver and placenta. Drug Metab Dispos 17:271-4
Gole, D J; Pirat, J L; Kamenka, J M et al. (1988) Hydroxy metabolites of phencyclidine. Identification and quantitation of two novel metabolites. Drug Metab Dispos 16:386-91
Domino, E F; Gole, D; Koek, W (1987) Metaphit, a proposed phencyclidine receptor acylator: disruption of mouse motor behavior and absence of PCP antagonist activity. J Pharmacol Exp Ther 243:95-100
Holsztynska, E J; Domino, E F (1986) Quantitation of phencyclidine, its metabolites, and derivatives by gas chromatography with nitrogen-phosphorus detection: application for in vivo and in vitro biotransformation studies. J Anal Toxicol 10:107-15
Lal, J; Krutak-Krol, H; Domino, E F (1986) Comparative antitussive effects of dextrorphan, dextromethorphan and phencyclidine. Arzneimittelforschung 36:1075-8
Domino, E F (1986) Comparison of phencyclidine and related substances with various indole, phenethylamine, and other psychotomimetics. Psychopharmacol Bull 22:973-6
Holsztynska, E J; Domino, E F (1985) Biotransformation of phencyclidine. Drug Metab Rev 16:285-320