Abstract

This research is concerned with the extent to which acutely and chronically administered methadone may interfere with types of behavior commonly observed in man. The goals are to delineate behavioral mechanisms of methadone's actions and its interactions with other drugs. These investigations will include deprivation conditions, the scheduling of consequences, conditioned reinforcement, and the repeated learning of behavioral chains.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
5R01DA002717-06
Application #
3207529
Study Section
Drug Abuse Clinical and Behavioral Research Review Committee (DACB)
Project Start
1980-09-01
Project End
1987-04-30
Budget Start
1986-05-01
Budget End
1987-04-30
Support Year
6
Fiscal Year
1986
Total Cost
Indirect Cost

  Institution

Name
University of Minnesota Twin Cities
Department
Type
Schools of Arts and Sciences
DUNS #
168559177
City
Minneapolis
State
MN
Country
United States
Zip Code
55455

  Publications

Jewett, D C; Cleary, J; Levine, A S et al. (1995) Effects of neuropeptide Y, insulin, 2-deoxyglucose, and food deprivation on food-motivated behavior. Psychopharmacology (Berl) 120:267-71
Schuh, K J; Schaal, D W; Thompson, T et al. (1994) Insulin, 2-deoxy-D-glucose, and food deprivation as discriminative stimuli in rats. Pharmacol Biochem Behav 47:317-24
Kovera, C A; Schaal, D W; Thompson, T et al. (1994) Behavioral and neurochemical mechanisms of opioid-antidepressant interactions. Pharmacol Biochem Behav 48:47-52
Jewett, D C; Cleary, J; Schaal, D W et al. (1993) [Leu31,Pro34]neuropeptide Y (NPY), but not NPY 20-36, produces discriminative stimulus effects similar to NPY and induces food intake. Brain Res 631:129-32
Rudski, J M; Schaal, D W; Thompson, T et al. (1992) Effects of methadone on free feeding in satiated rats. Pharmacol Biochem Behav 43:1033-7
Jewett, D C; Cleary, J; Levine, A S et al. (1992) Effects of neuropeptide Y on food-reinforced behavior in satiated rats. Pharmacol Biochem Behav 42:207-12
Jewett, D C; Schaal, D W; Cleary, J et al. (1991) The discriminative stimulus effects of neuropeptide Y. Brain Res 561:165-8
Macenski, M J; Cleary, J; Thompson, T (1990) Effects on opioid-induced rate reductions by doxepin and bupropion. Pharmacol Biochem Behav 37:247-52
Poling, A; Cleary, J; Berens, K et al. (1990) Neuroleptics and learning: effects of haloperidol, molindone, mesoridazine and thioridazine on the behavior of pigeons under a repeated acquisition procedure. J Pharmacol Exp Ther 255:1240-5
Nader, M A; Thompson, T (1989) Interaction of reinforcement history with methadone on responding maintained under a fixed-interval schedule. Pharmacol Biochem Behav 32:643-9

Showing the most recent 10 out of 18 publications