The proposed research is designed to study the behavioral pharmacology of cocaine in humans, characterizing its effects on measures of learning and performance as well as its subjective effects. We plan to study the interaction of cocaine with alcohol and marijuana using a battery of learning, performance and subjective measures. We are particularly interested in evaluating the toxicity of cocaine when it is taken repeatedly for several days at a time, a pattern common to the illicit cocaine abuser. In addition to evaluating its effects during drug taking, we will evaluate a possible """"""""crash"""""""" effect when drug taking stops, and its role as a potential setting condition in the reinitiation of cocaine use. We will also investigate the neurochemical mechanisms of cocaine's reinforcing properties, utilizing a drug choice paradigm and pretreating with various monoamine blockers. Finally, we will examine cocaine's reinforcing properties as they interact with its effects on other reinforcers in the environment. Thus, in evaluating cocaine's effects on behavior we will try to separate out its motoric and reinforcing effects on performance, as well as delineating the extent to which these effects contribute to enhanced reinforcing effectiveness of other reinforcers.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
2R01DA003818-04
Application #
3563662
Study Section
Drug Abuse Clinical and Behavioral Research Review Committee (DACB)
Project Start
1984-08-01
Project End
1992-07-31
Budget Start
1987-08-01
Budget End
1988-07-31
Support Year
4
Fiscal Year
1987
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Type
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Foltin, R W; Haney, M (2000) Conditioned effects of environmental stimuli paired with smoked cocaine in humans. Psychopharmacology (Berl) 149:24-33
Fischman, M W; Johanson, C E (1998) Ethical and practical issues involved in behavioral pharmacology research that administers drugs of abuse to human volunteers. Behav Pharmacol 9:479-98
Logan, J; Volkow, N D; Fowler, J S et al. (1997) Concentration and occupancy of dopamine transporters in cocaine abusers with [11C]cocaine and PET. Synapse 27:347-56
Foltin, R W; Fischman, M W; Levin, F R (1995) Cardiovascular effects of cocaine in humans: laboratory studies. Drug Alcohol Depend 37:193-210
Foltin, R W; Fischman, M W (1994) Cocaine self-administration research: treatment implications. NIDA Res Monogr 145:139-62
Foltin, R W; Fischman, M W; Pippen, P A et al. (1993) Behavioral effects of cocaine alone and in combination with ethanol or marijuana in humans. Drug Alcohol Depend 32:93-106
Fischman, M W; Foltin, R W (1992) Self-administration of cocaine by humans: a laboratory perspective. Ciba Found Symp 166:165-73;discussion 173-80
Foltin, R W; Fischman, M W (1992) The cardiovascular and subjective effects of intravenous cocaine and morphine combinations in humans. J Pharmacol Exp Ther 261:623-32
Foltin, R W; Fischman, M W (1992) Self-administration of cocaine by humans: choice between smoked and intravenous cocaine. J Pharmacol Exp Ther 261:841-9
Fischman, M W; Foltin, R W (1992) A laboratory model for evaluating potential treatment medications in humans. NIDA Res Monogr 119:165-9

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