Although the direct effects of nicotine on the brain are presumably responsible for the major reinforcing effects of cigarette smoking, peripheral actions of tobacco smoke, including those of nicotine, may account for important secondary reinforcing properties of cigarette smoking. This proposal deals with the subjective reactions to the interaction of cigarette smoke with the linings and receptors of the mouth, throat, and respiratory tract. Non-nicotine components of smoke, broadly known as tar, have been shown by us to play a role in smoking and we will study the reinforcing effects of this substance. The result should throw further light on the process of smoking and help to engineer a more rational approach to the control of the habit.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
5R01DA003848-02
Application #
3208614
Study Section
Drug Abuse Clinical and Behavioral Research Review Committee (DACB)
Project Start
1985-09-01
Project End
1988-08-31
Budget Start
1986-09-30
Budget End
1987-08-31
Support Year
2
Fiscal Year
1986
Total Cost
Indirect Cost
Name
University of California Los Angeles
Department
Type
Schools of Medicine
DUNS #
119132785
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Jarvik, M E; Caskey, N H; Rose, J E et al. (1989) Anxiolytic effects of smoking associated with four stressors. Addict Behav 14:379-86
Jarvik, M E; Saniga, S S; Herskovic, J E et al. (1989) Potentiation of cigarette craving and satisfaction by two types of meals. Addict Behav 14:35-41