Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
7R01DA004072-04
Application #
3209093
Study Section
(DABB)
Project Start
1986-08-01
Project End
1992-03-31
Budget Start
1989-06-01
Budget End
1992-03-31
Support Year
4
Fiscal Year
1988
Total Cost
Indirect Cost
Name
West Virginia University
Department
Type
Schools of Medicine
DUNS #
191510239
City
Morgantown
State
WV
Country
United States
Zip Code
26506
Royland, J E; Konat, G; Wiggins, R C (1993) Abnormal upregulation of myelin genes underlies the critical period of myelination in undernourished developing rat brain. Brain Res 607:113-6
Gu, J; Yassini, P; Goldberg, G et al. (1993) Cocaine cytotoxicity in serum-free environment: C6 glioma cell culture. Neurotoxicology 14:19-22
Wiggins, R C (1992) Pharmacokinetics of cocaine in pregnancy and effects on fetal maturation. Clin Pharmacokinet 22:85-93
Zhu, W; Kanoh, M; Ye, P et al. (1992) Retinoic acid-regulated expression of proteolipid protein and myelin-associated glycoprotein genes in C6 glioma cells. J Neurosci Res 31:745-50
Ye, P; Kanoh, M; Zhu, W et al. (1992) Cyclic AMP-induced upregulation of proteolipid protein and myelin associated glycoprotein gene expression in C6 cells. J Neurosci Res 31:578-83
Laszkiewicz, I; Wiggins, R C; Konat, G (1992) Ascorbic acid upregulates myelin gene expression in C6 glioma cells. Metab Brain Dis 7:157-64
Royland, J; Klinkhachorn, P; Konat, G et al. (1992) How much undernourishment is required to retard brain myelin development. Neurochem Int 21:269-74
Kanoh, M; Ye, P; Zhu, W et al. (1991) Effect of culture conditions on PLP and MAG gene expression in rat glioma C6 cells. Metab Brain Dis 6:133-43
Wiggins, R C; Ruiz, B (1990) Development under the influence of cocaine. I. A comparison of the effects of daily cocaine treatment and resultant undernutrition on pregnancy and early growth in a large population of rats. Metab Brain Dis 5:85-99
Qiao, J T; Dougherty, P M; Wiggins, R C et al. (1990) Effects of microiontophoretic application of cocaine, alone and with receptor antagonists, upon the neurons of the medial prefrontal cortex, nucleus accumbens and caudate nucleus of rats. Neuropharmacology 29:379-85

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