The behavioral manifestations and complications of marijuana smoking are probably associated with changes in brain function. With the advent of noninvasive measurement techniques, it is now possible to quantify cerebral blood flow (CBF) and cerebral metabolism (CMR), two indices of brain function in human subjects noninvasively. No information is available on the effects of marijuana on CBF and CMR. The study proposed here is divided into two sections. In Section I, CBF, behavior and mood will be measured before and thrice after smoking high-potency marijuana (2.5% THC), low potency marijuana (1% THC) and a placebo in 48 experienced marijuana smokers (ES and 48 inexperienced marijuana smokers (IS). The high-potency and low- potency marijuana and a placebo will be administered to all subjects and each individual would have had a total of 12 CBF measurements. CBF measurements in this section will be performed with the 133Xenon inhalation technique. The second section involves the measurement of CBF and CMR for oxygen together with behavior and mood before and twice after smoking high-potency (2.5% THC) marijuana (16 ES and 16 IS) or a placebo (8 ES and 8 IS). The measurements will be carried out with Positron Emissin Tomography (PET).
| Wilson, W; Mathew, R; Turkington, T et al. (2000) Brain morphological changes and early marijuana use: a magnetic resonance and positron emission tomography study. J Addict Dis 19:22-Jan |
| Mathew, R J; Wilson, W H; Chiu, N Y et al. (1999) Regional cerebral blood flow and depersonalization after tetrahydrocannabinol administration. Acta Psychiatr Scand 100:67-75 |
| Mathew, R J; Wilson, W H; Turkington, T G et al. (1998) Cerebellar activity and disturbed time sense after THC. Brain Res 797:183-9 |
| Mathew, R J; Wilson, W H; Coleman, R E et al. (1997) Marijuana intoxication and brain activation in marijuana smokers. Life Sci 60:2075-89 |
| Mathew, R J; Wilson, W H; Lowe, J V et al. (1996) Acute changes in cranial blood flow after cocaine hydrochloride. Biol Psychiatry 40:609-16 |
| Mathew, R J; Georgi, J; Wilson, W H et al. (1996) A retrospective study of the concept of spirituality as understood by recovering individuals. J Subst Abuse Treat 13:67-73 |
| Mathew, R J; Georgi, J; Wilson, W H et al. (1995) Substance abuse consultation in a teaching hospital. N C Med J 56:329-33 |
| Wilson, W H; Ellinwood, E H; Mathew, R J et al. (1994) Effects of marijuana on performance of a computerized cognitive-neuromotor test battery. Psychiatry Res 51:115-25 |
| Mathew, R J; Wilson, W H; Humphreys, D et al. (1993) Depersonalization after marijuana smoking. Biol Psychiatry 33:431-41 |
| Mathew, R J; Wilson, W H (1993) Acute changes in cerebral blood flow after smoking marijuana. Life Sci 52:757-67 |
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