The purpose of this grant is to determine the interactions between stress, smoking, and nicotine and whether public speaking, as a representative stressor, will increase smoking nicotine seeking, and influence blood nicotine levels. Three hypotheses will be tested. The first proposes that increased smoking during stress represents increased nicotine seeking. The second predicts that stress causes increased nicotine depletion secondary to acidification of urine and consequent increased excretion of nicotine. The third investigates whether smokers under stress seek to restore blood levels of nicotine to baseline levels or whether they seek reinforcement from increased levels of nicotine. The outcome of the experiments will determine how the investigation of the underlying physiological and pharmacological mechanisms of the stress nicotine interaction will proceed.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
5R01DA005111-02
Application #
3211166
Study Section
(SRCD)
Project Start
1987-09-30
Project End
1990-08-31
Budget Start
1988-09-01
Budget End
1989-08-31
Support Year
2
Fiscal Year
1988
Total Cost
Indirect Cost
Name
University of California Los Angeles
Department
Type
Hospitals
DUNS #
119132785
City
Los Angeles
State
CA
Country
United States
Zip Code
90095