Abstract

A wide variety of studies have indicated that electrophysiological measures are sensitive to the effects of nicotine and nicotine deprivation. In addition, the predisposition to use tobacco appears to be genetically influenced and is related to differences in various personality dimensions. These findings are reviewed and it is concluded that electrophysiological measures in conjunction with a personality inventory may provide a sensitive metric with which to discriminate individuals prone to use tobacco. The present proposal will employ electroencephalographic (EEG) and event-related potential (ERP) techniques to assess individuals who smoke and who do not smoke. These groups will be selected so that representative individuals who vary from low to medium to high on the sensation-seeking personality scale will be studied, with equal numbers of male and female subjects assessed. The nature of the approach will provide a comprehensive data set on the possible central nervous system differences, as revealed by electrophysiological measures, between smokers and non-smokers with respect to personality variables that are related to the predisposition to use tobacco. The results of the proposed study will determine: (1) whether EEG and ERPs can be used as markers or predictors for increased likelihood for tobacco use in predisposed individuals, (2) whether smokers differ from nonsmokers with respect to specific EEG and ERP measures and personality, and (3) whether males differ from females with respect to these factors.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
5R01DA008363-03
Application #
2414593
Study Section
Special Emphasis Panel (SRCD)
Project Start
1995-05-05
Project End
1999-04-30
Budget Start
1997-05-01
Budget End
1999-04-30
Support Year
3
Fiscal Year
1997
Total Cost
Indirect Cost

  Institution

Name
Scripps Research Institute
Department
Type
DUNS #
City
La Jolla
State
CA
Country
United States
Zip Code
92037

  Publications

Polich, John; Criado, Jose R (2006) Neuropsychology and neuropharmacology of P3a and P3b. Int J Psychophysiol 60:172-85
Struber, Daniel; Polich, John (2002) P300 and slow wave from oddball and single-stimulus visual tasks: inter-stimulus interval effects. Int J Psychophysiol 45:187-96
Ilan, A B; Polich, J (2001) Tobacco smoking and event-related brain potentials in a Stroop task. Int J Psychophysiol 40:109-18
Hoffman, L D; Polich, J (1999) P300, handedness, and corpus callosal size: gender, modality, and task. Int J Psychophysiol 31:163-74
Ravden, D; Polich, J (1999) On P300 measurement stability: habituation, intra-trial block variation, and ultradian rhythms. Biol Psychol 51:59-76
Hoffman, L D; Friedmann, A; Saltman, P et al. (1999) Neuroelectric assessment of nutrient intake. Int J Psychophysiol 32:93-106
Bennington, J Y; Polich, J (1999) Comparison of P300 from passive and active tasks for auditory and visual stimuli. Int J Psychophysiol 34:171-7
Ilan, A B; Polich, J (1999) P300 and response time from a manual Stroop task. Clin Neurophysiol 110:367-73
Ilan, A B; Polich, J (1999) Tobacco smoking and memory scanning: behavioral and event-related potential effects. Nicotine Tob Res 1:233-40
Comerchero, M D; Polich, J (1999) P3a and P3b from typical auditory and visual stimuli. Clin Neurophysiol 110:24-30

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