Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
5R01DA008951-03
Application #
2121832
Study Section
Drug Abuse Biomedical Research Review Committee (DABR)
Project Start
1994-05-01
Project End
1997-04-30
Budget Start
1996-06-05
Budget End
1997-04-30
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Pharmacology
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Bot, G; Blake, A D; Li, S et al. (1998) Fentanyl and its analogs desensitize the cloned mu opioid receptor. J Pharmacol Exp Ther 285:1207-18
Bot, G; Blake, A D; Li, S et al. (1998) Mutagenesis of the mouse delta opioid receptor converts (-)-buprenorphine from a partial agonist to an antagonist. J Pharmacol Exp Ther 284:283-90
Bot, G; Blake, A D; Li, S et al. (1998) Mutagenesis of a single amino acid in the rat mu-opioid receptor discriminates ligand binding. J Neurochem 70:358-65
Tallent, M; Dichter, M A; Reisine, T (1998) Differential regulation of the cloned kappa and mu opioid receptors. Neuroscience 85:873-85
Blake, A D; Bot, G; Freeman, J C et al. (1997) Differential opioid agonist regulation of the mouse mu opioid receptor. J Biol Chem 272:782-90
Bot, G; Blake, A D; Li, S et al. (1997) Opioid regulation of the mouse delta-opioid receptor expressed in human embryonic kidney 293 cells. Mol Pharmacol 52:272-81
Blake, A D; Bot, G; Li, S et al. (1997) Differential agonist regulation of the human kappa-opioid receptor. J Neurochem 68:1846-52
Blake, A D; Bot, G; Tallent, M et al. (1997) Molecular regulation of opioid receptors. Receptors Channels 5:231-5
Law, S F; Reisine, T (1997) Changes in the association of G protein subunits with the cloned mouse delta opioid receptor on agonist stimulation. J Pharmacol Exp Ther 281:1476-86
Reisine, T; Law, S F; Blake, A et al. (1996) Molecular mechanisms of opiate receptor coupling to G proteins and effector systems. Ann N Y Acad Sci 780:168-75

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