Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
1R01DA010167-01A1
Application #
2123620
Study Section
Human Development Research Subcommittee (NIDA)
Project Start
1996-09-01
Project End
1999-06-30
Budget Start
1996-09-01
Budget End
1997-06-30
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
078861598
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Fecho, K; Lysl, D T (2001) Acute effects of heroin on the cellularity of the spleen and the apoptosis of splenic leukocytes. Adv Exp Med Biol 493:153-62
Nelson, C J; Lysle, D T (2001) Morphine modulation of the contact hypersensitivity response: characterization of immunological changes. Clin Immunol 98:370-7
Lysle, D T; How, T (2000) Heroin modulates the expression of inducible nitric oxide synthase. Immunopharmacology 46:181-92
Carrigan, K A; Nelson, C J; Lysle, D T (2000) Endomorphin-1 induces antinociception without immunomodulatory effects in the rat. Psychopharmacology (Berl) 151:299-305
Fecho, K; Lysle, D T (2000) Heroin-induced alterations in leukocyte numbers and apoptosis in the rat spleen. Cell Immunol 202:113-23
Nelson, C J; Schneider, G M; Lysle, D T (2000) Involvement of central mu- but not delta- or kappa-opioid receptors in immunomodulation. Brain Behav Immun 14:170-84
Fecho, K; Nelson, C J; Lysle, D T (2000) Phenotypic and functional assessments of immune status in the rat spleen following acute heroin treatment. Immunopharmacology 46:193-207
Nelson, C J; Carrigan, K A; Lysle, D T (2000) Naltrexone administration attenuates surgery-induced immune alterations in rats. J Surg Res 94:172-7
Lysle, D T; How, T (1999) Endogenous opioids regulate the expression of inducible nitric oxide synthase by splenocytes. J Pharmacol Exp Ther 288:502-8
Nelson, C J; How, T; Lysle, D T (1999) Enhancement of the contact hypersensitivity reaction by acute morphine administration at the elicitation phase. Clin Immunol 93:176-83

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