Proposed is a prospective dynamic cohort study to determine the prevalence and incidence of HIV infection in recently initiated young injection drug users (IDUs), or """"""""initiates"""""""", and young non-injection drug users or NIUs (e.g., smoke crack, sniff heroin, etc.), and to identify correlates and risk factors for injection and for transition into IDU. Eligibility or IDUs is age 15-30 years with initiation within past 5 years; NIUs is age 15-30 with use started >1 but <10 years before entry. The 400 initiates and 200 NIUs will be recruited using street outreach techniques to a stationary or mobile clinic and East and Central Harlem. Recruited over 5 years, participants will undergo interviews and testing for HIV, HBV and HCV at entry, 6 and 12 months post-entry. Building upon our prior work, the interview will include """"""""new"""""""" variables )physical/sexual abuse, psychiatric condition, social networks/social support, type/frequency non-injection drugs); established variables will include demographics, drug and sex practices, and circumstances of IDU initiation. Analyses for correlates of infection will include logistic regression, and analysis of incidence will include person-time and poisson regression. Analysis of transition into IDU will include a case-control analysis of initiates and NIUs matched by age and interview interval for the year prior to initiation of the IDU case, using conditional logistic regression, prospective transition will use survival-methods. This study will provide new information to develop strategies and to better target primary prevention for blood-borne infections and injection drug use.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
3R01DA012801-03S1
Application #
6588727
Study Section
Special Emphasis Panel (ZRG1 (01))
Program Officer
Hartsock, Peter
Project Start
2000-02-10
Project End
2005-01-31
Budget Start
2002-06-01
Budget End
2003-01-31
Support Year
3
Fiscal Year
2002
Total Cost
$77,004
Indirect Cost
Name
New York Academy of Medicine
Department
Type
DUNS #
075239632
City
New York
State
NY
Country
United States
Zip Code
10029
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Crawford, Natalie D; Vlahov, David (2010) Progress in HIV reduction and prevention among injection and noninjection drug users. J Acquir Immune Defic Syndr 55 Suppl 2:S84-7
Bohnert, Amy S B; Tracy, Melissa; Galea, Sandro (2009) Circumstances and witness characteristics associated with overdose fatality. Ann Emerg Med 54:618-24
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Ompad, Danielle C; Fuller, Crystal M; Chan, Christina A et al. (2008) Correlates of illicit methadone use in New York City: a cross-sectional study. BMC Public Health 8:375
Coffin, Phillip O; Tracy, Melissa; Bucciarelli, Angela et al. (2007) Identifying injection drug users at risk of nonfatal overdose. Acad Emerg Med 14:616-23
Fuller, Crystal M; Galea, Sandro; Caceres, Wendy et al. (2007) Multilevel community-based intervention to increase access to sterile syringes among injection drug users through pharmacy sales in New York City. Am J Public Health 97:117-24
Galea, Sandro; Nandi, Ari; Coffin, Phillip O et al. (2006) Heroin and cocaine dependence and the risk of accidental non-fatal drug overdose. J Addict Dis 25:79-87
Bryant, W K; Ompad, D C; Sisco, S et al. (2006) Determinants of influenza vaccination in hard-to-reach urban populations. Prev Med 43:60-70

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