Abstract

This proposal seeks to investigate the process of menopause among HIV-infected women.
The specific aims are to describe: 1) the impact of HIV infection and drug use on menopausal symptoms and biologic markers; 2) attitudes and knowledge about menopause among HIV infected and drug using women, 3) the impact of H IV infection and drug use on bone mineral density before and after menopause: and 4) impact of HIV infection and antiretroviral therapy (HAART) on dyslipidemia, insulin resistance, and development of post-menopausal cardiovascular disease. The proposal is for a five-year prospective study of 750 middle-aged women in the Bronx, half of whom are HIV infected, and half at risk for HIV infection. A significant number of the participants will come from existing cohorts HIV Epidemiologic Research Study (HERS) which is ending and HIV Epidemiologic Research on Outcomes Study (HEROS) which will continue until 2002. Women will be recruited from the community to complete the newly proposed cohort.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
5R01DA013564-02
Application #
6379087
Study Section
Special Emphasis Panel (ZRG1-AARR-1 (06))
Program Officer
Davenny, Katherine
Project Start
2000-09-20
Project End
2005-08-31
Budget Start
2001-09-01
Budget End
2002-08-31
Support Year
2
Fiscal Year
2001
Total Cost
$1,017,145
Indirect Cost

  Institution

Name
Montefiore Medical Center (Bronx, NY)
Department
Type
DUNS #
City
New York
State
NY
Country
United States
Zip Code
10467

  Publications

W Batchelder, Abigail; Lounsbury, David W; Palma, Anton et al. (2016) Importance of substance use and violence in psychosocial syndemics among women with and at-risk for HIV. AIDS Care 28:1316-20
Sharma, Anjali; Flom, Peter L; Rosen, Clifford J et al. (2015) Racial differences in bone loss and relation to menopause among HIV-infected and uninfected women. Bone 77:24-30
Factor, S H; Lo, Y; Schoenbaum, E et al. (2013) Incident hypertension in older women and men with or at risk for HIV infection. HIV Med 14:337-46
Polsky, Sarit; Floris-Moore, Michelle; Schoenbaum, Ellie E et al. (2011) Incident hyperglycaemia among older adults with or at-risk for HIV infection. Antivir Ther 16:181-8
Sharma, Anjali; Cohen, Hillel W; Freeman, Ruth et al. (2011) Prospective evaluation of bone mineral density among middle-aged HIV-infected and uninfected women: Association between methadone use and bone loss. Maturitas 70:295-301
Cieloszyk, Kinga; Hartel, Diana; Moskaleva, Galina et al. (2009) Effects of hepatitis C virus infection on menopause status and symptoms. Menopause 16:401-6
Floris-Moore, Michelle; Fayad, Zahi A; Berman, Joan W et al. (2009) Association of HIV viral load with monocyte chemoattractant protein-1 and atherosclerosis burden measured by magnetic resonance imaging. AIDS 23:941-9
Santoro, Nanette; Fan, Maria; Maslow, BatSheva et al. (2009) Women and HIV infection: the makings of a midlife crisis. Maturitas 64:160-4
Milan, Felise B; Arnsten, Julia H; Klein, Robert S et al. (2008) Use of complementary and alternative medicine in inner-city persons with or at risk for HIV infection. AIDS Patient Care STDS 22:811-6
Hartel, Diana; Lo, Yungtai; Bauer, Carolyn et al. (2008) Attitudes toward menopause in HIV-infected and at-risk women. Clin Interv Aging 3:561-6

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