? Although rates of cigarette smoking are declining in the general population, rates of smoking among people with schizophrenia remain markedly high. Quit rates in these smokers are virtually zero. Few studies have systematically examined biological and behavioral factors that affect smoking in this population. The long-term objectives of this research program are to learn how biological and behavioral variables contribute to smoking addiction in these patients, and to use this information to develop strategies of reducing smoking in people with schizophrenia. This study will investigate, under laboratory conditions, the separate and combined effects of nicotine replacement (42 mg versus placebo) and sensorimotor replacement (access to denicotinized cigarettes versus no access) on smoking behavior in smokers with schizophrenia. We will also investigate effects in smokers who are matched on age, gender distribution, daily smoking rate and nicotine dependence, but do not have current psychiatric illness. We will also investigate effects of these interventions on urges to smoke, nicotine withdrawal symptoms, psychiatric symptoms, and cognitive task performance, and examine whether effects on these variables mediate effects on smoking. Relevance: We anticipate that this project will expand existing knowledge concerning factors that affect smoking in people with schizophrenia and heavy smokers without current mental illness. In turn, this information could be used to develop novel treatment strategies for these smokers. ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
2R01DA014002-05
Application #
7029144
Study Section
Special Emphasis Panel (ZDA1-RXL-E (17))
Program Officer
Montoya, Ivan
Project Start
2001-04-01
Project End
2010-03-31
Budget Start
2006-06-01
Budget End
2007-03-31
Support Year
5
Fiscal Year
2006
Total Cost
$314,583
Indirect Cost
Name
Brown University
Department
Miscellaneous
Type
Schools of Medicine
DUNS #
001785542
City
Providence
State
RI
Country
United States
Zip Code
02912
Tidey, Jennifer W; Cassidy, Rachel N; Miller, Mollie E (2016) Smoking Topography Characteristics of Very Low Nicotine Content Cigarettes, With and Without Nicotine Replacement, in Smokers With Schizophrenia and Controls. Nicotine Tob Res 18:1807-12
AhnAllen, Christopher G; Bidwell, L Cinnamon; Tidey, Jennifer W (2015) Cognitive effects of very low nicotine content cigarettes, with and without nicotine replacement, in smokers with schizophrenia and controls. Nicotine Tob Res 17:510-4
Tidey, Jennifer W; Rohsenow, Damaris J; Kaplan, Gary B et al. (2013) Separate and combined effects of very low nicotine cigarettes and nicotine replacement in smokers with schizophrenia and controls. Nicotine Tob Res 15:121-9
Ahnallen, Christopher G; Tidey, Jennifer W (2011) Personalized smoking environment cue reactivity in smokers with schizophrenia and controls: a pilot study. Psychiatry Res 188:286-8
MacKillop, James; Tidey, Jennifer W (2011) Cigarette demand and delayed reward discounting in nicotine-dependent individuals with schizophrenia and controls: an initial study. Psychopharmacology (Berl) 216:91-9
Murphy, James G; MacKillop, James; Tidey, Jennifer W et al. (2011) Validity of a demand curve measure of nicotine reinforcement with adolescent smokers. Drug Alcohol Depend 113:207-14
Tidey, Jennifer W; Rohsenow, Damaris J (2009) Intention to quit moderates the effect of bupropion on smoking urge. Nicotine Tob Res 11:308-12
Tidey, Jennifer W; Rohsenow, Damaris J (2009) Smoking expectancies and intention to quit in smokers with schizophrenia, schizoaffective disorder and non-psychiatric controls. Schizophr Res 115:310-6
Adolfo, Amy B; AhnAllen, Christopher G; Tidey, Jennifer W (2009) Effects of smoking cues on caffeine urges in heavy smokers and caffeine consumers with and without schizophrenia. Schizophr Res 107:192-7
Tidey, Jennifer W; Rohsenow, Damaris J; Kaplan, Gary B et al. (2008) Effects of smoking abstinence, smoking cues and nicotine replacement in smokers with schizophrenia and controls. Nicotine Tob Res 10:1047-56

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