This competitive revision seeks to expand on the parent grant to provide an in-depth and rigorous psychometric evaluation of nicotine dependence (ND) symptoms by using an innovative method (Integrative Data Analysis: IDA) to pool the two study data sets used in the parent grant and, using the pooled data, apply a novel statistical method (Moderated Nonlinear Factor Analysis: MNLFA) to evaluate the psychometric properties of ND symptoms from three commonly used measures of nicotine dependence: the DSM-IV, the Nicotine Dependence Syndrome Scale (NDSS), and the modified Fagerstrom Tolerance Questionnaire (FTQ). In the past, combining substance use data sets to obtain more powerful tests of hypotheses due to increases in sample size, heterogeneity, and base rates of ND, has been prohibitive primarily because of differences across studies in the ways in which constructs are measured. However, IDA is a method for pooling data sets despite differences in study populations, design, and measures. IDA permits considerably more powerful, more comprehensive, and more rigorous studies than can be achieved by studying single study data sets independently. Furthermore, new statistical methods (MNLFA) have been developed that permit tests of similarity (invariance) in ND symptom properties (in terms of how the symptoms relate to the underlying ND construct and their likelihood of endorsement at different levels of the construct) across studies and measures, as well as permitting a simultaneous evaluation of invariance as a function of individual risk factors. The proposed research extends the parent study in several ways. First, it proposes two new aims: 1) to conduct a rigorous psychometric analysis of ND symptoms to test invariance across studies on the pooled data set and 2) to test invariance of these symptoms as a function of depression and alcohol use disorders. This psychometric evaluation will inform how differences in measures of ND and these individual risk factors influence the meaning and subsequent scoring of an ND construct. Finally, a third aim is to use a combined ND symptom score for each individual, resulting from the models tested in the first two aims, to cross validate the specific aims of the parent grant regarding the relation between smoking exposure and nicotine sensitivity. The purpose is to conduct a more powerful test of the parent study hypotheses by using this new ND score that has a common metric across studies despite differences in measurement and other study characteristics and that takes into account potential differences in the psychometric properties of the symptoms as a function of depression and alcohol use disorders. This application has significant potential to advance the goals of OppNet through application of new and innovative methodological and statistical methods to advance and optimize the measurement of ND by identifying ND symptoms that are invariant across studies despite differences in study design and measures. Results can inform the measurement of ND and the extent to which symptoms from different ND measures can be combined to develop an optimal measure of ND.

Public Health Relevance

This research will provide a greater understanding of the measurement of nicotine dependence symptoms in young smokers. The proposed research is expected to inform further development of a brief but highly accurate assessment to identify young smokers who are at greatest risk for continued and heavier smoking and to inform targeted interventions for these young smokers.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
3R01DA022313-02S1
Application #
8039777
Study Section
Special Emphasis Panel (ZRG1-RPHB-K (85))
Program Officer
Wanke, Kay
Project Start
2007-01-01
Project End
2011-09-29
Budget Start
2010-09-30
Budget End
2011-09-29
Support Year
2
Fiscal Year
2010
Total Cost
$248,850
Indirect Cost
Name
Wesleyan University
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
145683954
City
Middletown
State
CT
Country
United States
Zip Code
06459
Selya, Arielle S; Dierker, Lisa; Rose, Jennifer S et al. (2016) Early-Emerging Nicotine Dependence Has Lasting and Time-Varying Effects on Adolescent Smoking Behavior. Prev Sci 17:743-50
Selya, Arielle S; Updegrove, Nicole; Rose, Jennifer S et al. (2015) Nicotine-dependence-varying effects of smoking events on momentary mood changes among adolescents. Addict Behav 41:65-71
Dierker, Lisa; Selya, Arielle; Piasecki, Thomas et al. (2013) Alcohol problems as a signal for sensitivity to nicotine dependence and future smoking. Drug Alcohol Depend 132:688-93
Rose, Jennifer S; Dierker, Lisa C; Hedeker, Donald et al. (2013) An integrated data analysis approach to investigating measurement equivalence of DSM nicotine dependence symptoms. Drug Alcohol Depend 129:25-32
Selya, Arielle S; Wakschlag, Lauren S; Dierker, Lisa C et al. (2013) Exploring alternate processes contributing to the association between maternal smoking and the smoking behavior among young adult offspring. Nicotine Tob Res 15:1873-82
Selya, Arielle S; Dierker, Lisa C; Rose, Jennifer S et al. (2013) Time-varying effects of smoking quantity and nicotine dependence on adolescent smoking regularity. Drug Alcohol Depend 128:230-7
Rose, Jennifer S; Lee, Chien-Ti; Selya, Arielle S et al. (2012) DSM-IV alcohol abuse and dependence criteria characteristics for recent onset adolescent drinkers. Drug Alcohol Depend 124:88-94
Tan, Xianming; Shiyko, Mariya P; Li, Runze et al. (2012) A time-varying effect model for intensive longitudinal data. Psychol Methods 17:61-77
Zhan, Weihai; Dierker, Lisa C; Rose, Jennifer S et al. (2012) The natural course of nicotine dependence symptoms among adolescent smokers. Nicotine Tob Res 14:1445-52
Dierker, Lisa; Swendsen, Joel; Rose, Jennifer et al. (2012) Transitions to regular smoking and nicotine dependence in the Adolescent National Comorbidity Survey (NCS-A). Ann Behav Med 43:394-401

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