Drug of abuse such as opiates have been shown to exert immunomodulatory effects and thereby serve as a cofactor in the progression of HIV-1 infection. Opiate and HIV target areas in brain such as basal ganglia and cortex that are enriched in 5 opioid receptors. Previous studies have shown that opiates act synergistically with HIV proteins (Tat and gp120) to potentiate HIV- related neurotoxicity, which ultimately leads to progression of NeuroAIDS. Currently, there is no treatment available to alleviate the synergistic effects of opiates and HIV, especially due to impenetrability of therapeutic molecules across the blood brain barrier (BBB). Therefore development of a drug delivery system containing an 5 opioid antagonist, a neuroprotective agent and ART that can cross BBB may have significant therapeutic advantage for treatment of opiate addiction and NeuroAIDS. In recent years, nanoparticle based delivery systems have shown promising approach for drug targeting to the brain. In the present proposal, we will develop a unique magnetically guided nanocarrier bound to CTOP (BBB impenetrable
This application has significant relevance to the purpose of the PAS-08-186, drug of abuse such as opiates have been shown to exert immunomodulatory effects and thereby serve as a cofactor in the progression of HIV-1 infection. Currently, there is no treatment available to alleviate the synergistic neurotoxicity of opiates and HIV, especially due to impenetrability of therapeutic molecules across the BBB. This project will evaluate a novel magnetically guided nanocarrier drug delivery system for simultaneous targeting of CTOP, BDNF and AZTTP across the BBB, thereby reduce opiate addiction and also NeuroAIDS in HIV infected subjects who are opiate users.
| Vashist, Arti; Kaushik, Ajeet; Vashist, Atul et al. (2018) Nanogels as potential drug nanocarriers for CNS drug delivery. Drug Discov Today 23:1436-1443 |
| Jayant, Rahul Dev; Atluri, Venkata S R; Tiwari, Sneham et al. (2017) Novel nanoformulation to mitigate co-effects of drugs of abuse and HIV-1 infection: towards the treatment of NeuroAIDS. J Neurovirol 23:603-614 |
| Kaushik, Ajeet; Tiwari, Sneham; Jayant, Rahul D et al. (2017) Electrochemical Biosensors for Early Stage Zika Diagnostics. Trends Biotechnol 35:308-317 |
| Vashist, Arti; Kaushik, Ajeet; Alexis, Kayla et al. (2017) Bioresponsive Injectable Hydrogels for On-demand Drug Release and Tissue Engineering. Curr Pharm Des 23:3595-3602 |
| Kaushik, Ajeet; Nikkhah-Moshaie, Roozbeh; Sinha, Raju et al. (2017) Investigation of ac-magnetic field stimulated nanoelectroporation of magneto-electric nano-drug-carrier inside CNS cells. Sci Rep 7:45663 |
| Vashist, Arti; Kaushik, Ajeet; Vashist, Atul et al. (2016) Recent trends on hydrogel based drug delivery systems for infectious diseases. Biomater Sci 4:1535-1553 |
| Samikkannu, Thangavel; Atluri, Venkata S R; Nair, Madhavan P N (2016) HIV and Cocaine Impact Glial Metabolism: Energy Sensor AMP-activated protein kinase Role in Mitochondrial Biogenesis and Epigenetic Remodeling. Sci Rep 6:31784 |
| Atluri, Venkata Subba Rao; Pilakka-Kanthikeel, Sudheesh; Garcia, Gabriella et al. (2016) Effect of Cocaine on HIV Infection and Inflammasome Gene Expression Profile in HIV Infected Macrophages. Sci Rep 6:27864 |
| Jayant, Rahul Dev; Sosa, Daniela; Kaushik, Ajeet et al. (2016) Current status of non-viral gene therapy for CNS disorders. Expert Opin Drug Deliv 13:1433-45 |
| Kaushik, Ajeet; Jayant, Rahul Dev; Tiwari, Sneham et al. (2016) Nano-biosensors to detect beta-amyloid for Alzheimer's disease management. Biosens Bioelectron 80:273-287 |
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