In response to PA-13-080: Accelerating the Pace of Drug Abuse Research Using Existing Research Data, this competing renewal Trajectories of Nonmedical Prescription Drug Misuse builds on our parent R01 and proposes to use multiple cohorts of nationally representative longitudinal data to assess the individual patterns and trajectories of medical and nonmedical use of four classes of prescription medications (i.e., opioids, sedatives, stimulants, tranquilizers) from adolescence to adulthood and the development of substance use disorders (SUDs) and other long-term adverse consequences in adulthood. Despite increases in the medical and nonmedical use of prescription medications among adolescents and young adults in the U.S., relatively few prospective longitudinal studies have investigated the development of SUDs and other adverse consequences in adulthood. While there have been advances in understanding nonmedical use of prescription medications and short-term consequences, considerable gaps in knowledge remain due to limitations in measurement and study designs. Findings from our parent R01 suggest a great deal of heterogeneity in the nonmedical use of prescription medications during adolescence and young adulthood (ages 18-22). The Monitoring the Future (MTF) study provides a valuable opportunity to address new research questions that will lead to a more comprehensive understanding of medical and nonmedical use of prescription medications. We propose several secondary analyses using 39 nationally representative cohorts of approximately 585,000 high school seniors between 1976 and 2014 from the MTF study. The MTF longitudinal panel sample features 23 separate cohorts of approximately 55,200 high school seniors (modal age 18) who were followed 3-4 years (modal ages 21-22), 7-8 years (modal ages 25-26), and 17 years (modal age 35) later, resulting in four longitudinal waves of data for each cohort. The MTF study represents the only nationally representative longitudinal study that has sufficient measures and sample size to test for potential sex, racial, and socioeconomic status differences and to meet the objectives of our study, which aims to: 1) assess the individual patterns and trajectories of medical and nonmedical use of four prescription medication classes (i.e., opioids, sedatives, stimulants, tranquilizers) during the transition from adolescence (age 18) to adulthood (age 35) using cross-sectional and longitudinal panel data; 2) examine the associations between individual patterns and trajectories of medical and nonmedical use of four medication classes from adolescence to adulthood and development of SUDs and other adverse consequences (e.g., health problems, hospitalizations, and legal problems) during adulthood (age 35) using longitudinal panel data; and 3) investigate the risk and protective factors for individual patterns and trajectories of medical and nonmedical use of four prescription medication classes from adolescence to adulthood associated with development of SUDs and other consequences during adulthood (age 35) using a theory-based developmental model and longitudinal panel data.

Public Health Relevance

Despite increases in the medical and nonmedical use of prescription medication among adolescents and young adults in the U.S., relatively little is known about the longitudinal trajectories and related long-term adverse consequences associated with medical and nonmedical use of prescription medications among adolescents. The proposed study will help inform the development of prevention efforts by examining patterns of medical and nonmedical use of prescription medication associated with the development of substance use disorders and other adverse consequences using a nationally representative sample. Findings will help guide clinical practice and future research by examining new research questions related to the patterns and trajectories of medical and nonmedical use of prescription medications and identification of adolescents at greatest risk for developing substance use disorders and other long-term adverse consequences.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
5R01DA031160-06
Application #
9274941
Study Section
Special Emphasis Panel (ZRG1-PSE-P (55)R)
Program Officer
Obrien, Moira
Project Start
2015-07-01
Project End
2018-05-31
Budget Start
2017-06-01
Budget End
2018-05-31
Support Year
6
Fiscal Year
2017
Total Cost
$232,500
Indirect Cost
$82,500
Name
University of Michigan Ann Arbor
Department
Type
Organized Research Units
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Harbaugh, Calista M; Lee, Jay S; Hu, Hsou Mei et al. (2018) Persistent Opioid Use Among Pediatric Patients After Surgery. Pediatrics 141:
Voepel-Lewis, Terri; Zikmund-Fisher, Brian J; Boyd, Carol J et al. (2018) Effect of a Scenario-tailored Opioid Messaging Program on Parents' Risk Perceptions and Opioid Decision-making. Clin J Pain 34:497-504
McCabe, Sean Esteban; West, Brady T; Strobbe, Stephen et al. (2018) Persistence/recurrence of and remission from DSM-5 substance use disorders in the United States: Substance-specific and substance-aggregated correlates. J Subst Abuse Treat 93:38-48
McCabe, Sean Esteban; Veliz, Philip; Schulenberg, John E (2018) How Collegiate Fraternity and Sorority Involvement Relates to Substance Use During Young Adulthood and Substance Use Disorders in Early Midlife: A National Longitudinal Study. J Adolesc Health 62:S35-S43
Schepis, Ty S; McCabe, Sean Esteban; Teter, Christian J (2018) Sources of opioid medication for misuse in older adults: results from a nationally representative survey. Pain 159:1543-1549
Matthews, Alicia K; McCabe, Sean Esteban; Lee, Joseph G L et al. (2018) Differences in smoking prevalence and eligibility for low-dose computed tomography (LDCT) lung cancer screening among older U.S. adults: role of sexual orientation. Cancer Causes Control 29:769-774
McCabe, Sean Esteban; Wilens, Timothy E; Boyd, Carol J et al. (2018) Age-specific risk of substance use disorders associated with controlled medication use and misuse subtypes in the United States. Addict Behav 90:285-293
Boyd, C J; West, B; McCabe, S E (2018) Does misuse lead to a disorder? The misuse of prescription tranquilizer and sedative medications and subsequent substance use disorders in a U.S. longitudinal sample. Addict Behav 79:17-23
Teter, Christian J; DiRaimo, Christopher G; West, Brady T et al. (2018) Nonmedical Use of Prescription Stimulants Among US High School Students to Help Study: Results From a National Survey. J Pharm Pract :897190018783887
McCabe, Sean Esteban; Teter, Christian J; Boyd, Carol J et al. (2018) Sources of Prescription Medication Misuse Among Young Adults in the United States: The Role of Educational Status. J Clin Psychiatry 79:

Showing the most recent 10 out of 71 publications