The proposed studies will use behavioral methods to assess localization of function at the level of the olfactory bulb. Rats with lesions of 2-DG identified areas of the olfactory bulb will be tested using olfactometric methods for their ability to detect, discriminate and recognize odors. In a separate experiment rats with removal of large areas of the bulb will be tested on a variety of odor detection and discrimination tasks. These studies will provide a test for the functional significance of recent anatomical and physiological evidence for topographic localization of odor coding.
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McBride, S A; Slotnick, B (1997) The olfactory thalamocortical system and odor reversal learning examined using an asymmetrical lesion paradigm in rats. Behav Neurosci 111:1273-84 |
Darling, F M; Slotnick, B M (1994) Odor-cued taste avoidance: a simple and efficient method for assessing olfactory detection, discrimination and memory in the rat. Physiol Behav 55:817-22 |
Lu, X C; Slotnick, B M (1994) Recognition of propionic acid vapor after removal of the olfactory bulb area associated with high 2-DG uptake. Brain Res 639:26-32 |
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