This proposal hypothesizes that reinfection with CMV occurs frequently in some populations, with symptomatic congenital CMV infection occurring in offspring of immune mothers more frequently than previously recognized. Therefore, a case-control study of intrauterine CMV transmission among young women (less than 20 years of age) who were CMV seropositive prior to pregnancy is proposed with the following specific aims: (1) to determine the rates of reinfection with CMV among young, low-income CMV seropositive women, (2) to determine whether exposure to young children and sexual behavior are associated with reinfection among seropositive women, and (3) to assess whether maternal reinfection increases risk for intrauterine CMV transmission among women with preexisting immunity and (4) to characterize the antiviral antibody responses in those women who did and did not transmit CMV to their infants.
| Pati, Sunil K; Novak, Zdenek; Purser, Misty et al. (2012) Strain-specific neutralizing antibody responses against human cytomegalovirus envelope glycoprotein N. Clin Vaccine Immunol 19:909-13 |
| Yamamoto, Aparecida Y; Mussi-Pinhata, Marisa Marcia; Isaac, Myriam de Lima et al. (2011) Congenital cytomegalovirus infection as a cause of sensorineural hearing loss in a highly immune population. Pediatr Infect Dis J 30:1043-6 |
| Yamamoto, Aparecida Yulie; Mussi-Pinhata, Marisa Marcia; Boppana, Suresh B et al. (2010) Human cytomegalovirus reinfection is associated with intrauterine transmission in a highly cytomegalovirus-immune maternal population. Am J Obstet Gynecol 202:297.e1-8 |
| Ross, Shannon A; Arora, Nitin; Novak, Zdenek et al. (2010) Cytomegalovirus reinfections in healthy seroimmune women. J Infect Dis 201:386-9 |
| Arora, Nitin; Novak, Zdenek; Fowler, Karen B et al. (2010) Cytomegalovirus viruria and DNAemia in healthy seropositive women. J Infect Dis 202:1800-3 |
| Novak, Zdenek; Ross, Shannon A; Patro, Raj Kumar et al. (2009) Enzyme-linked immunosorbent assay method for detection of cytomegalovirus strain-specific antibody responses. Clin Vaccine Immunol 16:288-90 |
| Novak, Zdenek; Ross, Shannon A; Patro, Raj Kumar et al. (2008) Cytomegalovirus strain diversity in seropositive women. J Clin Microbiol 46:882-6 |
| Dar, Lalit; Pati, Sunil Kumar; Patro, A Raj Kumar et al. (2008) Congenital cytomegalovirus infection in a highly seropositive semi-urban population in India. Pediatr Infect Dis J 27:841-3 |
| Fowler, Karen B; Boppana, Suresh B (2006) Congenital cytomegalovirus (CMV) infection and hearing deficit. J Clin Virol 35:226-31 |
| Ross, Shannon A; Novak, Zdenek; Ashrith, Guha et al. (2005) Association between genital tract cytomegalovirus infection and bacterial vaginosis. J Infect Dis 192:1727-30 |
Showing the most recent 10 out of 14 publications
