Abstract

The long range aim of this project is to predict vocal fold movement and sound generation in the larynx from neural inputs. Central to the research project is the design and implementation of a complete quantitative neuromuscular model of the larynx and to adapt this model to existing data or to data to be experimentally obtained as part of the project. The planned work consists in: establishing the dynamic contractile properties and constitutive equations for all laryngeal muscles; to develop a new 3D finite element model that allows simulation of laryngeal posturing; investigating to which degree the compartments of the thyroarytenoid muscle effect adduction, pitch and vocal register in phonation; to determine the role of laryngeal reflexes in vocal fold posturing and in neurologic instabilities of voicing; and finally to develop a set of test utterances that will test the motor capabilities of the larynx and vocal disorders of laryngeal control.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Research Project (R01)
Project #
5R01DC004347-03
Application #
6523519
Study Section
Special Emphasis Panel (ZRG1-IFCN-5 (05))
Program Officer
Shekim, Lana O
Project Start
2000-09-01
Project End
2005-08-31
Budget Start
2002-09-01
Budget End
2003-08-31
Support Year
3
Fiscal Year
2002
Total Cost
$365,064
Indirect Cost

  Institution

Name
University of Iowa
Department
Other Health Professions
Type
Schools of Arts and Sciences
DUNS #
041294109
City
Iowa City
State
IA
Country
United States
Zip Code
52242

  Publications

Klemuk, Sarah A; Lu, Xiaoying; Hoffman, Henry T et al. (2010) Phonation threshold pressure predictions using viscoelastic properties up to 1,400 Hz of injectables intended for Reinke's space. Laryngoscope 120:995-1001
Titze, Ingo R; Finnegan, Eileen M; Laukkanen, Anne-Maria et al. (2008) Laryngeal muscle activity in giggle: a damped oscillation model. J Voice 22:644-8
Titze, Ingo R; Laukkanen, Anne-Maria (2007) Can vocal economy in phonation be increased with an artificially lengthened vocal tract? A computer modeling study. Logoped Phoniatr Vocol 32:147-56
Hunter, Eric J; Alipour, Fariborz; Titze, Ingo R (2007) Sensitivity of elastic properties to measurement uncertainties in laryngeal muscles with implications for voice fundamental frequency prediction. J Voice 21:641-50
Titze, Ingo R; Hunter, Eric J (2007) A two-dimensional biomechanical model of vocal fold posturing. J Acoust Soc Am 121:2254-60
Hunter, Eric J; Titze, Ingo R (2007) Refinements in modeling the passive properties of laryngeal soft tissue. J Appl Physiol 103:206-19
Chan, Roger W; Titze, Ingo R (2006) Dependence of phonation threshold pressure on vocal tract acoustics and vocal fold tissue mechanics. J Acoust Soc Am 119:2351-62
Hunter, Eric J; Svec, Jan G; Titze, Ingo R (2006) Comparison of the produced and perceived voice range profiles in untrained and trained classical singers. J Voice 20:513-26
Fuja, Tannin J; Probst-Fuja, Megan N; Titze, Ingo R (2006) Changes in expression of extracellular matrix genes, fibrogenic factors, and actin cytoskeletal organization in retinol treated and untreated vocal fold stellate cells. Matrix Biol 25:59-67
Fuja, Tannin J; Ostrem, Erin M; Probst-Fuja, Megan N et al. (2006) Differential cell adhesion to vocal fold extracellular matrix constituents. Matrix Biol 25:240-51

Showing the most recent 10 out of 18 publications