The long-term objective of this research is to study the development, deterioration, and plasticity of auditory pathways mediating human communication. Specifically, our aim is to examine the development of the central auditory system as reflected by latencies of P1 and Ni cortical auditory evoked potentials in normal-hearing children and in congenitally deaf children after they are fitted with a cochlear implant. Three projects are proposed. The goal of the first project is to provide a comprehensive account of the development of P1 and Ni latencies in normal-hearing children. These data will serve as a baseline against which to compare the performance of cochlear implant recipients. In the second project we will examine whether, and to what extent, pediatric cochlear implant recipients show a delay in the development of P1 and NI latencies. The goal is to determine the age after which cochlear implantation would be in a physiologically degenerate auditory system, or conversely, the age before which implantation would be in a relatively 'normal' auditory system. The third project is a longitudinal assessment of the development of P1 and NI latencies in pediatric implant users. The goal is to determine the time period over which plasticity remains a property of the central auditory pathways. Overall, our experiments are designed to assess the consequences on the developing central auditory system of initiating electrical stimulation at different ages. The results of these experiments could provide an estimate of the upper age limit for implantation into a highly plastic and/or relatively non-degenerate auditory system.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Research Project (R01)
Project #
7R01DC004552-02
Application #
6553209
Study Section
Special Emphasis Panel (ZRG1-IFCN-6 (01))
Program Officer
Donahue, Amy
Project Start
2001-06-01
Project End
2006-05-31
Budget Start
2002-01-01
Budget End
2002-05-31
Support Year
2
Fiscal Year
2001
Total Cost
$235,772
Indirect Cost
Name
University of Texas-Dallas
Department
Psychology
Type
Other Domestic Higher Education
DUNS #
City
Richardson
State
TX
Country
United States
Zip Code
75080
Gilley, Phillip M; Sharma, Anu; Mitchell, Teresa V et al. (2010) The influence of a sensitive period for auditory-visual integration in children with cochlear implants. Restor Neurol Neurosci 28:207-18
Le Bel, Ronald M; Pineda, Jaime A; Sharma, Anu (2009) Motor-auditory-visual integration: The role of the human mirror neuron system in communication and communication disorders. J Commun Disord 42:299-304
Gilley, Phillip M; Sharma, Anu; Dorman, Michael F (2008) Cortical reorganization in children with cochlear implants. Brain Res 1239:56-65
King, Katrina Agung; Campbell, Julia; Sharma, Anu et al. (2008) The representation of voice onset time in the cortical auditory evoked potentials of young children. Clin Neurophysiol 119:2855-61
Dorman, Michael F; Sharma, Anu; Gilley, Phillip et al. (2007) Central auditory development: evidence from CAEP measurements in children fit with cochlear implants. J Commun Disord 40:284-94
Gilley, Phillip M; Sharma, Anu; Dorman, Michael et al. (2006) Minimization of cochlear implant stimulus artifact in cortical auditory evoked potentials. Clin Neurophysiol 117:1772-82
Bauer, Paul W; Sharma, Anu; Martin, Kathryn et al. (2006) Central auditory development in children with bilateral cochlear implants. Arch Otolaryngol Head Neck Surg 132:1133-6
Gilley, Phillip M; Sharma, Anu; Dorman, Michael et al. (2006) Abnormalities in central auditory maturation in children with language-based learning problems. Clin Neurophysiol 117:1949-56
Sharma, Anu; Martin, Kathryn; Roland, Peter et al. (2005) P1 latency as a biomarker for central auditory development in children with hearing impairment. J Am Acad Audiol 16:564-73
Sharma, Anu; Dorman, Michael F; Kral, Andrej (2005) The influence of a sensitive period on central auditory development in children with unilateral and bilateral cochlear implants. Hear Res 203:134-43

Showing the most recent 10 out of 13 publications