The long-term goals of the proposed research are to examine the effect of advancing age on auditory learning, and to identify the intracerebral sources underlying behaviorally measured gains in skills acquired with training. More specifically, using behavioral and physiological measures, we will characterize the effects of age on the acquisition, generalization, and retention of learned temporal cues. Motivation for this study stems from the fact that older adults, with and without hearing loss, have difficulty perceiving various types of time-varying acoustic cues. Moreover, there is increasing evidence that impaired perception results, in part, from age-related factors affecting neural synchrony. Over the past decade we, and others, have shown that auditory training can alter synchronous neural patterns and improve the perception of the trained temporal cue. However, much of what we know about auditory training and auditory plasticity is limited to young adults and animals. Because the largest proportion of the population with communication disorders is elderly, it is important to determine if older adults can benefit from auditory training, or, if age limits the capacity for neural and perceptual change. ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Research Project (R01)
Project #
5R01DC007705-02
Application #
7109258
Study Section
Auditory System Study Section (AUD)
Program Officer
Donahue, Amy
Project Start
2005-09-01
Project End
2010-08-31
Budget Start
2006-09-01
Budget End
2007-08-31
Support Year
2
Fiscal Year
2006
Total Cost
$212,228
Indirect Cost
Name
University of Washington
Department
Other Health Professions
Type
Schools of Arts and Sciences
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
Baltzell, Lucas S; Billings, Curtis J (2014) Sensitivity of offset and onset cortical auditory evoked potentials to signals in noise. Clin Neurophysiol 125:370-80
Clinard, Christopher G; Tremblay, Kelly L (2013) Aging degrades the neural encoding of simple and complex sounds in the human brainstem. J Am Acad Audiol 24:590-9; quiz 643-4
Ross, Bernhard; Jamali, Shahab; Tremblay, Kelly L (2013) Plasticity in neuromagnetic cortical responses suggests enhanced auditory object representation. BMC Neurosci 14:151
Ben-David, Boaz M; Campeanu, Sandra; Tremblay, Kelly L et al. (2011) Auditory evoked potentials dissociate rapid perceptual learning from task repetition without learning. Psychophysiology 48:797-807
Bierer, Julie Arenberg; Faulkner, Kathleen F; Tremblay, Kelly L (2011) Identifying cochlear implant channels with poor electrode-neuron interfaces: electrically evoked auditory brain stem responses measured with the partial tripolar configuration. Ear Hear 32:436-44
Won, Jong Ho; Clinard, Christopher G; Kwon, Seeyoun et al. (2011) Relationship between behavioral and physiological spectral-ripple discrimination. J Assoc Res Otolaryngol 12:375-93
Billings, Curtis J; Tremblay, Kelly L; Miller, Christi W (2011) Aided cortical auditory evoked potentials in response to changes in hearing aid gain. Int J Audiol 50:459-67
Alain, Claude; Campeanu, Sandra; Tremblay, Kelly (2010) Changes in sensory evoked responses coincide with rapid improvement in speech identification performance. J Cogn Neurosci 22:392-403
Tremblay, Kelly L; Inoue, Kayo; McClannahan, Katrina et al. (2010) Repeated stimulus exposure alters the way sound is encoded in the human brain. PLoS One 5:e10283
Clinard, Christopher G; Tremblay, Kelly L; Krishnan, Ananthanarayan R (2010) Aging alters the perception and physiological representation of frequency: evidence from human frequency-following response recordings. Hear Res 264:48-55

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