Principal Investigator/Program Director (Last, first, middle): Zeng, Fan-Gang ABSTRACT The present administrative supplement proposes to examine the relationship between tinnitus and cognition and to treat tinnitus in patients with Alzheimer's disease and related dementia (ADRD). Tinnitus is a hearing disorder that produces auditory perception without auditory stimulation and affects 13-52% of the ARDR population. Using the same experimental protocols as in the active parent award and building upon the preliminary work from a previous supplement, the proposed work will achieve the following specific aims.
Specific Aim 1 will investigate the relationship between tinnitus and cognition in ADRD patients. We predict that tinnitus severity will be positively correlated with cognitive decline.
Specific Aim 2 will use electric brain stimulation to treat tinnitus in the same patients. The main hypothesis is that, compared with typical non-ADRD subjects, the ADRD patients would require different electric stimulation parameters for optimal tinnitus suppression. We predict that dynamic brain electric stimulation will be more effective than steady-state ear electric stimulation in suppressing tinnitus in ADRD subjects. Tinnitus characterization may serve as a biomarker for monitoring the onset and progression of ADRD, while tinnitus suppression may delay or reduce cognitive decline and development of ADRD. Research Strategy

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Research Project (R01)
Project #
3R01DC015587-04S1
Application #
10121063
Study Section
Special Emphasis Panel (ZDC1)
Program Officer
Miller, Roger
Project Start
2016-08-16
Project End
2021-07-31
Budget Start
2019-08-01
Budget End
2020-07-31
Support Year
4
Fiscal Year
2020
Total Cost
Indirect Cost
Name
University of California Irvine
Department
Otolaryngology
Type
Schools of Medicine
DUNS #
046705849
City
Irvine
State
CA
Country
United States
Zip Code
92617
Zeng, Fan-Gang (2017) Challenges in Improving Cochlear Implant Performance and Accessibility. IEEE Trans Biomed Eng 64:1662-1664
Huang, Juan; Sheffield, Benjamin; Lin, Payton et al. (2017) Electro-Tactile Stimulation Enhances Cochlear Implant Speech Recognition in Noise. Sci Rep 7:2196