Resources Facilities The Eaton-Peabody Laboratories (EPL) at the Massachusetts Eye and Ear Infirmary (MEEI) occupies ~10,000 sq ft, 2500 sq ft and 2000 sq ft on floors 4, 6 and 3, respectively. The laboratory is fully equipped for neurophysiological, anatomic, histologic, immunohistochemical and molecular studies. Clinical The Masschusetts Eye and Ear Infirmary is a tertiary referral hospital and a teaching affiliate of Harvard Medical School. The hospital has state of the art facilities for care of patients with hearing loss. Animal There is a fully equipped animal care facility at MEEI, which includes two animal rooms (~400 sq. ft. each) reserved for use by members of EPL. The facility also includes rooms for acute and chronic animals. Computer Personal computers with internet access are available throughout the EPL. Computer facilities are maintained by full time computer programmer and systems analysts. Office The P.I. has a 200 sq ft office at MEEI adjacent to her dedicated laboratory space of ~1000 sq ft. Other The P.I. has access to the viral core facility at Massachusetts Eye and Ear. The core facility is fully equipped for customized viral vector design.

Public Health Relevance

Vestibular schwannoma (VS) is a non-cancerous intracranial tumor that can cause disabling problems, including hearing loss, tinnitus, balance disturbances and facial paralysis. No drug is FDA-approved to treat VS or the associated hearing loss. By studying human VS-secreted molecules that are likely mediators of hearing loss, we pave the way for future targeted therapies with broad relevance for human sensorineural hearing loss.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Research Project (R01)
Project #
3R01DC015824-02S1
Application #
9748044
Study Section
Auditory System Study Section (AUD)
Program Officer
Watson, Bracie
Project Start
2016-09-13
Project End
2021-08-31
Budget Start
2018-09-01
Budget End
2019-08-31
Support Year
2
Fiscal Year
2018
Total Cost
Indirect Cost
Name
Massachusetts Eye and Ear Infirmary
Department
Type
DUNS #
073825945
City
Boston
State
MA
Country
United States
Zip Code
Zhao, Yingchao; Liu, Pinan; Zhang, Na et al. (2018) Targeting the cMET pathway augments radiation response without adverse effect on hearing in NF2 schwannoma models. Proc Natl Acad Sci U S A 115:E2077-E2084
Ren, Yin; Sethi, Rosh K V; Stankovic, Konstantina M (2018) Acute Otitis Media and Associated Complications in United States Emergency Departments. Otol Neurotol 39:1005-1011
Sagers, Jessica E; Brown, Adam S; Vasilijic, Sasa et al. (2018) Computational repositioning and preclinical validation of mifepristone for human vestibular schwannoma. Sci Rep 8:5437
Landegger, Lukas D; Pan, Bifeng; Askew, Charles et al. (2017) A synthetic AAV vector enables safe and efficient gene transfer to the mammalian inner ear. Nat Biotechnol 35:280-284
Sagers, Jessica E; Landegger, Lukas D; Worthington, Steven et al. (2017) Human Cochlear Histopathology Reflects Clinical Signatures of Primary Neural Degeneration. Sci Rep 7:4884
?ahin, Mehmet ?lhan; Sagers, Jessica E; Stankovic, Konstantina M (2017) Cochlear Implantation: Vast Unmet Need to Address Deafness Globally. Otol Neurotol 38:786-787
Ren, Yin; Sagers, Jessica E; Landegger, Lukas D et al. (2017) Tumor-Penetrating Delivery of siRNA against TNF? to Human Vestibular Schwannomas. Sci Rep 7:12922
Landegger, Lukas D; Sagers, Jessica E; Dilwali, Sonam et al. (2017) A Unified Methodological Framework for Vestibular Schwannoma Research. J Vis Exp :
Landegger, Lukas D; Lee, Jong D; Linthicum Jr, Fred H et al. (2017) Cochlear Dysfunction is not Common in Human Meningioma of the Internal Auditory Canal. Otol Neurotol 38:e486-e489
Landegger, Lukas D; Dilwali, Sonam; Stankovic, Konstantina M (2017) Neonatal Murine Cochlear Explant Technique as an In Vitro Screening Tool in Hearing Research. J Vis Exp :