The long range goal of this research is to increase the efficacy of topical floride therapy of human enamel. Incorporation of fluoride in enamel from systemic ingestion during tooth formation is in the form of fluorhydroxyapatite and is caries preventive. Certain formulations of fluoride, phosphate and surface active agents have been shown to accelerate formation of firmly (presumably apatitically) bound fluoride in enamel from topical application in vitro. The proposed work includes further development of a liquid self-gelling formulation of tetraethoxysilane and an aqueous fluoride solution which gels in situ after application to the teeth thus prolonging the contact time between fluoride vehicle and tooth surface. Specifically, it is proposed (1) to assess in vitro how to maximize formation of firmly bound fluoride in enamel by incorporation of specific surface active agents in the system and (2) to study in rodents the caries inhibitive effect of such self-gelling compositions and of solutions of fluoride, phosphate and surface active agents. The proposed research will result in formulations which may be clinically tested for topical application to the teeth or for use in dentifraces and mouthwashes. The formulations will have the protential to be more effective than those currently in use with the same fluoride concentration or equally effective, but containing less fluoride.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Research Project (R01)
Project #
2R01DE005067-07
Application #
3219228
Study Section
Oral Biology and Medicine Study Section (OBM)
Project Start
1978-07-01
Project End
1987-12-31
Budget Start
1985-01-01
Budget End
1985-12-31
Support Year
7
Fiscal Year
1985
Total Cost
Indirect Cost
Name
Forsyth Institute
Department
Type
DUNS #
City
Cambridge
State
MA
Country
United States
Zip Code
Caslavska, V; Gron, P; Kent, R L et al. (1991) CaF2 in enamel biopsies 6 weeks and 18 months after fluoride treatment. Caries Res 25:21-6
Capilouto, M L; DePaola, P F; Gron, P (1990) In vivo study of slow-release fluoride resin and enamel uptake. Caries Res 24:441-5
Gron, P; Caslavska, V; Tamura, T et al. (1987) The caries inhibitory effect of repeated topical applications of NaF or NH4F in rodents. Caries Res 21:346-52
Caslavska, V; Gron, P; Ahern, J M (1987) Fluoride acquisition by enamel from solutions and self-gelling preparations. Caries Res 21:333-8
Caslavska, V; Gron, P; Kent, R (1987) Enhanced caries inhibition by certain NaF-surfactant combinations in animal models. J Dent Res 66:1159-61
Tamura, T; Gron, P; Caslavska, V et al. (1987) Effect of fluoride and selected cationic surfactants on caries in rodents. Caries Res 21:526-9
Caslavska, V; Gron, P; Picard, M et al. (1987) Comparison of the relative caries-inhibitory effect of sodium and ammonium fluoride administered in the drinking water to rats. Caries Res 21:62-7
Gron, P; Caslavska, V (1985) Self-gelling liquid composition for topical application of medications. Caries Res 19:228-31