This research will investigate the factors involved in long-term growth and adaptation of the craniofacial skeletal system following replacement of the mandibular condyle in growing Macaca mulatta. Growth of the maxilla and mandible after bilateral condylar replacement using autogenous 1) mandibular condyles, 2) bone, 3) sternal condyle of the clavicles, and 4) costochondral junction of ribs will be evaluated cephalometrically using 24 juvenile female Macaca mulatta as experimental subjects. Adaptations within the temporomandibular joints will be evaluated histologically two years following transplantation. Based upon previous studies in our laboratory, the following specific hypotheses, or predictions, are put forward: 1) bilateral replacement of the mandibular condyles with autogenous mandibular condyles will result in normal growth of the mandible; 2) bilateral replacement of the mandibular condyle with a bone graft will result in abnormal growth leading to a deficiency of mandibular growth; 3) bilateral replacement of the mandibular condyle with the costochondral junction of a rib will result in uncoordinated growth of the mandible, and; 4) bilateral replacement of the mandibular condyle with the sternal end of the clavicle will result in continued, harmonious growth of the mandible. The results of this study will have a direct and immediate impact on the related clinical problem of growth of the craniofacial complex following lack of growth of the mandibular condyles. The results will assist the surgeon in selecting a transplant which offers the patient a better chance of harmonious facial growth when used clinically to replace a defective mandibular condyle.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Research Project (R01)
Project #
5R01DE008824-05
Application #
2130200
Study Section
Oral Biology and Medicine Subcommittee 1 (OBM)
Project Start
1991-02-01
Project End
1996-01-31
Budget Start
1994-02-01
Budget End
1996-01-31
Support Year
5
Fiscal Year
1994
Total Cost
Indirect Cost
Name
Texas A&M Baylor College of Dentistry
Department
Other Basic Sciences
Type
Schools of Dentistry
DUNS #
City
Dallas
State
TX
Country
United States
Zip Code
75246
Ellis 3rd, Edward; Schneiderman, Emet D; Carlson, David S (2002) Growth of the mandible after replacement of the mandibular condyle: an experimental investigation in Macaca mulatta. J Oral Maxillofac Surg 60:1461-70; discussion 1470-1
Dibbets, J M; Carlson, D S (1995) Implications of temporomandibular disorders for facial growth and orthodontic treatment. Semin Orthod 1:258-72