Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Research Project (R01)
Project #
5R01DE010515-03
Application #
2131401
Study Section
Oral Biology and Medicine Subcommittee 1 (OBM)
Project Start
1994-04-01
Project End
1998-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Florida
Department
Dentistry
Type
Schools of Dentistry
DUNS #
073130411
City
Gainesville
State
FL
Country
United States
Zip Code
32611
Brayer, J B; Cha, S; Nagashima, H et al. (2001) IL-4-dependent effector phase in autoimmune exocrinopathy as defined by the NOD.IL-4-gene knockout mouse model of Sjogren's syndrome. Scand J Immunol 54:133-40
Cha, S; van Blockland, S C; Versnel, M A et al. (2001) Abnormal organogenesis in salivary gland development may initiate adult onset of autoimmune exocrinopathy. Exp Clin Immunogenet 18:143-60
Brayer, J; Lowry, J; Cha, S et al. (2000) Alleles from chromosomes 1 and 3 of NOD mice combine to influence Sjogren's syndrome-like autoimmune exocrinopathy. J Rheumatol 27:1896-904
Yamachika, S; Brayer, J; Oxford, G E et al. (2000) Aberrant proteolytic digestion of biglycan and decorin by saliva and exocrine gland lysates from the NOD mouse model for autoimmune exocrinopathy. Clin Exp Rheumatol 18:233-40
Humphreys-Beher, M G; Peck, A B (1999) New concepts for the development of autoimmune exocrinopathy derived from studies with the NOD mouse model. Arch Oral Biol 44 Suppl 1:S21-5
Humphreys-Beher, M G; Brayer, J; Yamachika, S et al. (1999) An alternative perspective to the immune response in autoimmune exocrinopathy: induction of functional quiescence rather than destructive autoaggression. Scand J Immunol 49:7-10
Yamachika, S; Nanni, J M; Nguyen, K H et al. (1998) Excessive synthesis of matrix metalloproteinases in exocrine tissues of NOD mouse models for Sjogren's syndrome. J Rheumatol 25:2371-80
Robinson, C P; Bounous, D I; Alford, C E et al. (1998) Aberrant expression and potential function for parotid secretory protein (PSP) in the NOD (non-obese diabetic) mouse. Adv Exp Med Biol 438:925-30
Robinson, C P; Brayer, J; Yamachika, S et al. (1998) Transfer of human serum IgG to nonobese diabetic Igmu null mice reveals a role for autoantibodies in the loss of secretory function of exocrine tissues in Sjogren's syndrome. Proc Natl Acad Sci U S A 95:7538-43
Robinson, C P; Cornelius, J; Bounous, D E et al. (1998) Characterization of the changing lymphocyte populations and cytokine expression in the exocrine tissues of autoimmune NOD mice. Autoimmunity 27:29-44

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