Saliva is normally inhibitory for HIV replication. One of the factors which may be involved in this is the primary defense factor in the oral cavity, namely secretory IgA. IgA is transported into secretions by secretory component (SC) synthesized by epithelial cells in the salivary glands. The expression of SC is regulated by cytokines. Since HIV infection has a profound effect on the immune system, the properties of salivary IgA antibodies of HIV infected patients will be examined including their specificity structure and function. Secondly, investigations will be initiated on the alterations of salivary cytokines or on cytokine expression by cells of the oral cavity which may influence oral manifestation of HIV infection. Third, the potential for intracellular formation of IgA anti-HIV/HIV complexes will be examined, which could lead to virus neutralization within epithelial cells in the oral cavity.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Research Project (R01)
Project #
5R01DE012146-04
Application #
2897137
Study Section
Special Emphasis Panel (ZDE1-YS (31))
Project Start
1996-09-30
Project End
2001-07-31
Budget Start
1999-08-01
Budget End
2000-07-31
Support Year
4
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of Alabama Birmingham
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
004514360
City
Birmingham
State
AL
Country
United States
Zip Code
35294
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