Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Research Project (R01)
Project #
1R01DE012165-01
Application #
2015445
Study Section
Special Emphasis Panel (ZDE1-YS (31))
Project Start
1996-09-30
Project End
2001-07-31
Budget Start
1996-09-30
Budget End
1997-07-31
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Kimura, Kotohiko; Huang, Ru Chih C (2016) Tetra-O-Methyl Nordihydroguaiaretic Acid Broadly Suppresses Cancer Metabolism and Synergistically Induces Strong Anticancer Activity in Combination with Etoposide, Rapamycin and UCN-01. PLoS One 11:e0148685
Huang, Ru Chih C; Chang, Chih Chuan; Mold, David (2006) Survivin-dependent and -independent pathways and the induction of cancer cell death by tetra-O-methyl nordihydroguaiaretic acid. Semin Oncol 33:479-85
Chang, Chih-Chuan; Heller, Jonathan D; Kuo, Jennifer et al. (2004) Tetra-O-methyl nordihydroguaiaretic acid induces growth arrest and cellular apoptosis by inhibiting Cdc2 and survivin expression. Proc Natl Acad Sci U S A 101:13239-44
Huang, Ru Chih C; Li, Yen; Giza, Paul E et al. (2003) Novel antiviral agent tetraglycylated nordihydroguaiaretic acid hydrochloride as a host-dependent viral inhibitor. Antiviral Res 58:57-64
Park, Richard; Giza, Paul E; Mold, David E et al. (2003) Inhibition of HSV-1 replication and reactivation by the mutation-insensitive transcription inhibitor tetra-O-glycyl-nordihydroguaiaretic acid. Antiviral Res 58:35-45
Abd-Elazem, Ibrahim S; Chen, Hong S; Bates, Robert B et al. (2002) Isolation of two highly potent and non-toxic inhibitors of human immunodeficiency virus type 1 (HIV-1) integrase from Salvia miltiorrhiza. Antiviral Res 55:91-106
Heller, J D; Kuo, J; Wu, T C et al. (2001) Tetra-O-methyl nordihydroguaiaretic acid induces G2 arrest in mammalian cells and exhibits tumoricidal activity in vivo. Cancer Res 61:5499-504
Hwu, J R; Tseng, W N; Gnabre, J et al. (1998) Antiviral activities of methylated nordihydroguaiaretic acids. 1. Synthesis, structure identification, and inhibition of tat-regulated HIV transactivation. J Med Chem 41:2994-3000
Chen, H; Teng, L; Li, J N et al. (1998) Antiviral activities of methylated nordihydroguaiaretic acids. 2. Targeting herpes simplex virus replication by the mutation insensitive transcription inhibitor tetra-O-methyl-NDGA. J Med Chem 41:3001-7