The overall purpose of this study is to determine the role of oral and systemic bone mineral density (BMD) in the development of new and progressive periodontal disease in postmenopausal women. We hypothesize that low BMD will be associated with both new and progressive periodontitis over time by increasing susceptibility to destructive periodontitis. We propose a longitudinal assessment of BMD and its role in establishment of periodontal disease in postmenopausal women with systematic studies using sensitive and accurate measures of skeletal and oral BMD, and periodontal disease. As part of the BMD assessment, we will further validate the methodology for oral BMD. In concert with these, assessment of a variety of potential co-risk factors for both low BMD and periodontitis will allow us to determine their contribution to this association. The systemic covariates include age, body mass index, smoking, alcohol, hormone use, socioeconomic and psychosocial factors, medications, medical and reproductive history, and diet. Local covariates include plaque, gingivitis, probing depth, previous dental care, and dental care habits. Study subjects will be recruited from an established cohort of postmenopausal women with baseline assessments of BMD and periodontitis as part of an ongoing cross-sectional study. We propose a 3-vear follow-up examination in 1000 postmenopausal women already enrolled in the NIH Women's Health Initiative study. To date, studies have not characterized the specific role of BMD either skeletal or mandibular on periodontal disease incidence and progression in a large cohort of postmenopausal women. Our preliminary cross-sectional studies have determined that skeletal BMD is associated with alveolar crestal height, tooth loss and clinical attachment loss. The proposed longitudinal study will have sufficient sample size and statistical power to assess the temporal relationship between BMD and periodontitis and the effects of a large set of co-risk factors and potential confounding factors affecting osteopenia, periodontal disease or both. This study provides a unique opportunity to define this relationship in a cost effective manner in a cohort of postmenopausal women under study as part of the Women's Health Initiative and has great practical significance. Low BMD is likely of considerable importance in the onset and progression of periodontitis. Hence once the relationship is established, modalities effective in the prevention and treatment of osteoporosis may prove useful for prevention and treatment of periodontitis and subsequent tooth loss.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Research Project (R01)
Project #
5R01DE013505-03
Application #
6755101
Study Section
Special Emphasis Panel (ZRG1-OBM-2 (01))
Program Officer
Canto, Maria Teresa
Project Start
2002-04-01
Project End
2006-03-31
Budget Start
2004-04-01
Budget End
2005-03-31
Support Year
3
Fiscal Year
2004
Total Cost
$490,680
Indirect Cost
Name
State University of New York at Buffalo
Department
Public Health & Prev Medicine
Type
Schools of Medicine
DUNS #
038633251
City
Buffalo
State
NY
Country
United States
Zip Code
14260
Banack, Hailey R; Genco, Robert J; LaMonte, Michael J et al. (2018) Cohort profile: the Buffalo OsteoPerio microbiome prospective cohort study. BMJ Open 8:e024263
Gordon, Joshua H; LaMonte, Michael J; Genco, Robert J et al. (2018) Association of clinical measures of periodontal disease with blood pressure and hypertension among postmenopausal women. J Periodontol 89:1193-1202
Mai, Xiaodan; Marshall, Britt; Hovey, Kathleen M et al. (2018) Risk factors for 5-year prospective height loss among postmenopausal women. Menopause 25:883-889
Nwizu, Ngozi N; Marshall, James R; Moysich, Kirsten et al. (2017) Periodontal Disease and Incident Cancer Risk among Postmenopausal Women: Results from the Women's Health Initiative Observational Cohort. Cancer Epidemiol Biomarkers Prev 26:1255-1265
Mai, Xiaodan; Sperrazza, Jill N; Marshall, Britt A et al. (2017) Inaccurate self-report of height and its impact on misclassification of body mass index in postmenopausal women. Menopause 24:484-489
Mai, Xiaodan; LaMonte, Michael J; Hovey, Kathleen M et al. (2016) Periodontal disease severity and cancer risk in postmenopausal women: the Buffalo OsteoPerio Study. Cancer Causes Control 27:217-28
Pavlesen, Sonja; Mai, Xiaodan; Wactawski-Wende, Jean et al. (2016) Vitamin D Status and Tooth Loss in Postmenopausal Females: The Buffalo Osteoporosis and Periodontal Disease (OsteoPerio) Study. J Periodontol 87:852-63
Mai, Xiaodan; Genco, Robert J; LaMonte, Michael J et al. (2016) Periodontal Pathogens and Risk of Incident Cancer in Postmenopausal Females: The Buffalo OsteoPerio Study. J Periodontol 87:257-67
Wang, Youjin; LaMonte, Michael J; Hovey, Kathleen M et al. (2015) Association of serum 17?-estradiol concentration, hormone therapy, and alveolar crest height in postmenopausal women. J Periodontol 86:595-605
LaMonte, Michael J; Williams, AnnaLynn M; Genco, Robert J et al. (2014) Association between metabolic syndrome and periodontal disease measures in postmenopausal women: the Buffalo OsteoPerio study. J Periodontol 85:1489-501

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