Abstract

In this multi-site, 5-year longitudinal study, infants with one of four types of single-suture craniosynostosis will be recruited: sagittal, metopic, right unilateral coronal, and left unilateral coronal (n=258). A case-matched """"""""control"""""""" group of healthy, normal infants (n=285) will also be followed. The long-term objectives are to chart the neurobehavioral course of single-suture fusions and to better understand how the developing cranium affects human brain growth and function.
Specific aims are to: (1) Clarify the neurobehavioral development and parental adjustment of infants with and without single-suture fusions at three time points in infancy and early childhood (just prior to cranioplastic surgery and twice post-surgery, at 18 and 36 months of age); (2) Among children with craniosynostosis, clarify relations between neurobehavioral development and abnormality in bone and brain tissue as indicated by measures taken pre-surgery CT scans; (3) Among children with unicoronal synostosis, clarify relations between neurobehavioral development and presence of genetic mutations; (4) Develop predictive models of 36-month outcomes for infants with craniosynostosis; and (5) Determine the relation between age of cranioplastic surgery and pre- and post- surgery neurobehavioral development. This research will take place in medical centers located in Seattle, Chicago, St. Louis and Atlanta. Seattle's Children's Hospital and Regional Medical Center is the lead agency.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Research Project (R01)
Project #
5R01DE013813-03
Application #
6606145
Study Section
Special Emphasis Panel (ZDE1-PW (32))
Program Officer
Riddle, Melissa
Project Start
2001-09-01
Project End
2006-06-30
Budget Start
2003-07-01
Budget End
2004-06-30
Support Year
3
Fiscal Year
2003
Total Cost
$848,261
Indirect Cost

  Institution

Name
Seattle Children's Hospital
Department
Type
DUNS #
048682157
City
Seattle
State
WA
Country
United States
Zip Code
98105

  Publications

Sun, Baiyang; Cloonan, Yona K; Collett, Brent R et al. (2017) Sleep Outcomes in Children With Single-Suture Craniosynostosis Compared With Unaffected Controls. Cleft Palate Craniofac J 54:734-738
Aldridge, Kristina; Collett, Brent R; Wallace, Erin R et al. (2017) Structural brain differences in school-age children with and without single-suture craniosynostosis. J Neurosurg Pediatr 19:479-489
Collett, Brent R; Kapp-Simon, Kathleen A; Wallace, Erin et al. (2017) Attention and executive function in children with and without single-suture craniosynostosis. Child Neuropsychol 23:83-98
Wallace, Erin R; Collett, Brent R; Kapp-Simon, Kathleen et al. (2016) Visuomotor Function in School-Age Children with Single-Suture Craniosynostosis. J Dev Behav Pediatr 37:483-90
Kapp-Simon, Kathleen A; Wallace, Erin; Collett, Brent R et al. (2016) Language, learning, and memory in children with and without single-suture craniosynostosis. J Neurosurg Pediatr 17:578-88
Gray, Kristen E; Kapp-Simon, Kathleen A; Starr, Jacqueline R et al. (2015) Predicting developmental delay in a longitudinal cohort of preschool children with single-suture craniosynostosis: is neurobehavioral assessment important? Dev Med Child Neurol 57:456-62
Birgfeld, Craig B; Dufton, Lynette; Naumann, Heather et al. (2015) Safety of Open Cranial Vault Surgery for Single-Suture Craniosynostosis: A Case for the Multidisciplinary Team. J Craniofac Surg 26:2052-8
Gray, Kristen E; Cradock, Mary Michaeleen; Kapp-Simon, Kathleen A et al. (2015) Longitudinal analysis of parenting stress in mothers and fathers of infants with and without single-suture craniosynostosis. Cleft Palate Craniofac J 52:3-11
Speltz, Matthew L; Collett, Brent R; Wallace, Erin R et al. (2015) Intellectual and academic functioning of school-age children with single-suture craniosynostosis. Pediatrics 135:e615-23
Cradock, Mary Michaeleen; Gray, Kristen E; Kapp-Simon, Kathleen A et al. (2015) Sex differences in the neurodevelopment of school-age children with and without single-suture craniosynostosis. Childs Nerv Syst 31:1103-11

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